Maturation of Mitochondrially Targeted Prx V Involves a Second Cleavage by Mitochondrial Intermediate Peptidase That Is Sensitive to Inhibition by H<sub>2</sub>O<sub>2</sub>

Maturation of Mitochondrially Targeted Prx V Involves a Second Cleavage by Mitochondrial Intermediate Peptidase That Is Sensitive to Inhibition by H<sub>2</sub>O<sub>2</sub>

Prx V mRNA contains two in-frame AUG codons, producing a long (L-Prx V) and short form of Prx V (S-Prx V), and mouse L-Prx V is expressed as a precursor protein containing a 49-amino acid N-terminal mitochondria targeting sequence. Here, we show that the N-terminal 41-residue sequence of L-Prx V is...

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Bibliographic Details
Main Authors: Juhyun Sim, Jiyoung Park, Hyun Ae Woo, Sue Goo Rhee
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Antioxidants
Subjects:
peroxiredoxin V
mitochondria targeting sequence
mitochondrial intermediate peptidase
hydrogen peroxide
Online Access:https://www.mdpi.com/2076-3921/10/3/346

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