| Summary: | Background: Unsafe injection is an important cause of transmitting blood-borne infections such as hepatitis B virus, human immunodeficiency virus, and hepatitis C virus. In a country-like India, health system usually suffers from the paucity of workforce and nursing personnel are the most susceptible to unsafe injection and needle stick injury. Aim: The present study was carried out with the aim to assess the knowledge and skills among nursing personnel regarding safe injection practices and to measure the change following training session. Materials and Methods: This was a hospital-based cross-sectional study, included all 230 nursing personnel those who were currently working in the hospital. A pretested, predesigned, standardized questionnaire was used. Everyday activity of the study was divided into three parts. First part of activity included pretest second part of activity consisted of 3–4 h training session and third part was posttest. The collected data were tabulated and analyzed using the SPSS Statistics for Windows, version 22.0. Results: Nearly 52.9% of the participants were aware of diseases transmitted through unsafe injection and 45.5% of participants were aware about appropriate sharp waste disposal. Only 20.6% of participants wore gloves before injection administration, and 56.1% used needle destroyer for disposing off the needles. Conclusion: Periodic reinforcement of the nursing personnel with hands on training sessions is the need of the hour to protect them from needle stick injuries and prevent the spread of blood borne pathogens in public at large.
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