Melanogenesis Inhibition by Homoisoflavavone Sappanone A from <em>Caesalpinia sappan</em>

Melanogenesis Inhibition by Homoisoflavavone Sappanone A from <em>Caesalpinia sappan</em>

Homoisoflavanone, sappanone A, was isolated from <em>Caesalpinia sappan</em> and proven to dose-dependently inhibit both melanogenesis and cellular tyrosinase activity via repressing tyrosinase gene expression in mouse B16 melanoma cells. To our knowledge, sappanone A is...

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Bibliographic Details
Main Authors: Hsiou-Yu Ding, Shih-Yu Chao, Te-Sheng Chang
Format: Article
Language:English
Published: MDPI AG 2012-08-01
Series:International Journal of Molecular Sciences
Subjects:
<em>Caesalpinia sappan</em>
inhibition
melanogenesis
sappanone A
tyrosinase
Online Access:http://www.mdpi.com/1422-0067/13/8/10359
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spelling doaj-3771b6bfa8034f48b8c2f1182b95eaa32020-11-25T00:54:37ZengMDPI AGInternational Journal of Molecular Sciences1422-00672012-08-01138103591036710.3390/ijms130810359Melanogenesis Inhibition by Homoisoflavavone Sappanone A from <em>Caesalpinia sappan</em>Hsiou-Yu DingShih-Yu ChaoTe-Sheng ChangHomoisoflavanone, sappanone A, was isolated from <em>Caesalpinia sappan</em> and proven to dose-dependently inhibit both melanogenesis and cellular tyrosinase activity via repressing tyrosinase gene expression in mouse B16 melanoma cells. To our knowledge, sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. Our results give a new impetus to the future search for other homoisoflavanone melanogenesis inhibitors.http://www.mdpi.com/1422-0067/13/8/10359<em>Caesalpinia sappan</em>inhibitionmelanogenesissappanone Atyrosinase
collection DOAJ
language English
format Article
sources DOAJ
author Hsiou-Yu Ding
Shih-Yu Chao
Te-Sheng Chang
spellingShingle Hsiou-Yu Ding
Shih-Yu Chao
Te-Sheng Chang
Melanogenesis Inhibition by Homoisoflavavone Sappanone A from <em>Caesalpinia sappan</em>
International Journal of Molecular Sciences
<em>Caesalpinia sappan</em>
inhibition
melanogenesis
sappanone A
tyrosinase
author_facet Hsiou-Yu Ding
Shih-Yu Chao
Te-Sheng Chang
author_sort Hsiou-Yu Ding
title Melanogenesis Inhibition by Homoisoflavavone Sappanone A from <em>Caesalpinia sappan</em>
title_short Melanogenesis Inhibition by Homoisoflavavone Sappanone A from <em>Caesalpinia sappan</em>
title_full Melanogenesis Inhibition by Homoisoflavavone Sappanone A from <em>Caesalpinia sappan</em>
title_fullStr Melanogenesis Inhibition by Homoisoflavavone Sappanone A from <em>Caesalpinia sappan</em>
title_full_unstemmed Melanogenesis Inhibition by Homoisoflavavone Sappanone A from <em>Caesalpinia sappan</em>
title_sort melanogenesis inhibition by homoisoflavavone sappanone a from <em>caesalpinia sappan</em>
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2012-08-01
description Homoisoflavanone, sappanone A, was isolated from <em>Caesalpinia sappan</em> and proven to dose-dependently inhibit both melanogenesis and cellular tyrosinase activity via repressing tyrosinase gene expression in mouse B16 melanoma cells. To our knowledge, sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. Our results give a new impetus to the future search for other homoisoflavanone melanogenesis inhibitors.
topic <em>Caesalpinia sappan</em>
inhibition
melanogenesis
sappanone A
tyrosinase
url http://www.mdpi.com/1422-0067/13/8/10359
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AT shihyuchao melanogenesisinhibitionbyhomoisoflavavonesappanoneafromltemgtcaesalpiniasappanltemgt
AT teshengchang melanogenesisinhibitionbyhomoisoflavavonesappanoneafromltemgtcaesalpiniasappanltemgt
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