Tissue Deposition and Residue Depletion in Broiler Exposed to Melamine-Contaminated Diets
To investigate the tissue deposition and elimination of melamine (MEL) in broilers, a total of 1 920 commercial 1-d-old male Cobb broilers were randomly allotted to 6 treatments with diets contaminated by MEL at 0, 2, 10, 30, 50, 100 mg kg-1 of diet for 42 d, and followed MEL withdrawal from diet at...
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doaj-377214cf65d04dc0be700e9a127e9aac2021-06-07T06:45:48ZengElsevierJournal of Integrative Agriculture2095-31192012-01-01111109115Tissue Deposition and Residue Depletion in Broiler Exposed to Melamine-Contaminated DietsXue-mei DING0Shi-ping BAI1Ke-ying ZHANG2Liang WANG3Cai-mei WU4Dai-wen CHEN5Gang JIA6Jie BAI7DING Xue-mei, Mobile: 13981603429; Institute of Animal Nutrition, Key Laboratory for Animal Disease-Resistance Nutrition of China, Ministry of Education, Sichuan Agricultural University, Yaan 625014, P.R. ChinaInstitute of Animal Nutrition, Key Laboratory for Animal Disease-Resistance Nutrition of China, Ministry of Education, Sichuan Agricultural University, Yaan 625014, P.R. ChinaCorrespondence ZHANG Ke-ying, Tel: +86-835-2885630; Institute of Animal Nutrition, Key Laboratory for Animal Disease-Resistance Nutrition of China, Ministry of Education, Sichuan Agricultural University, Yaan 625014, P.R. ChinaInstitute of Animal Nutrition, Key Laboratory for Animal Disease-Resistance Nutrition of China, Ministry of Education, Sichuan Agricultural University, Yaan 625014, P.R. ChinaInstitute of Animal Nutrition, Key Laboratory for Animal Disease-Resistance Nutrition of China, Ministry of Education, Sichuan Agricultural University, Yaan 625014, P.R. ChinaInstitute of Animal Nutrition, Key Laboratory for Animal Disease-Resistance Nutrition of China, Ministry of Education, Sichuan Agricultural University, Yaan 625014, P.R. ChinaInstitute of Animal Nutrition, Key Laboratory for Animal Disease-Resistance Nutrition of China, Ministry of Education, Sichuan Agricultural University, Yaan 625014, P.R. ChinaInstitute of Animal Nutrition, Key Laboratory for Animal Disease-Resistance Nutrition of China, Ministry of Education, Sichuan Agricultural University, Yaan 625014, P.R. ChinaTo investigate the tissue deposition and elimination of melamine (MEL) in broilers, a total of 1 920 commercial 1-d-old male Cobb broilers were randomly allotted to 6 treatments with diets contaminated by MEL at 0, 2, 10, 30, 50, 100 mg kg-1 of diet for 42 d, and followed MEL withdrawal from diet at 50 or 100 mg kg-1 of diet for 96 h. The MEL was found in residue of plasma, liver, kidney, breast, and leg muscle with the highest level in kidney and in dose response manner (except in kidney), but no time response (except in plasma). The MEL residue in organ tissue was below the safe level of 50 ?g mL-1 in blood or 50 ?g kg-1 in tissues proposed by the US FSIS when MEL in diet was lower (2 mg kg-1). The MEL in tissues was eliminated by withdrawal MEL from diets. The elimination half-life of MEL was from 3.2 to 6.6 h, and the clearance time, when MEL residue concentration under limit detection, was from 18.0 to 31.4 h.http://www.sciencedirect.com/science/article/pii/S1671292712607883melaminebroilerdepositionelimination |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xue-mei DING Shi-ping BAI Ke-ying ZHANG Liang WANG Cai-mei WU Dai-wen CHEN Gang JIA Jie BAI |
spellingShingle |
Xue-mei DING Shi-ping BAI Ke-ying ZHANG Liang WANG Cai-mei WU Dai-wen CHEN Gang JIA Jie BAI Tissue Deposition and Residue Depletion in Broiler Exposed to Melamine-Contaminated Diets Journal of Integrative Agriculture melamine broiler deposition elimination |
author_facet |
Xue-mei DING Shi-ping BAI Ke-ying ZHANG Liang WANG Cai-mei WU Dai-wen CHEN Gang JIA Jie BAI |
author_sort |
Xue-mei DING |
title |
Tissue Deposition and Residue Depletion in Broiler Exposed to Melamine-Contaminated Diets |
title_short |
Tissue Deposition and Residue Depletion in Broiler Exposed to Melamine-Contaminated Diets |
title_full |
Tissue Deposition and Residue Depletion in Broiler Exposed to Melamine-Contaminated Diets |
title_fullStr |
Tissue Deposition and Residue Depletion in Broiler Exposed to Melamine-Contaminated Diets |
title_full_unstemmed |
Tissue Deposition and Residue Depletion in Broiler Exposed to Melamine-Contaminated Diets |
title_sort |
tissue deposition and residue depletion in broiler exposed to melamine-contaminated diets |
publisher |
Elsevier |
series |
Journal of Integrative Agriculture |
issn |
2095-3119 |
publishDate |
2012-01-01 |
description |
To investigate the tissue deposition and elimination of melamine (MEL) in broilers, a total of 1 920 commercial 1-d-old male Cobb broilers were randomly allotted to 6 treatments with diets contaminated by MEL at 0, 2, 10, 30, 50, 100 mg kg-1 of diet for 42 d, and followed MEL withdrawal from diet at 50 or 100 mg kg-1 of diet for 96 h. The MEL was found in residue of plasma, liver, kidney, breast, and leg muscle with the highest level in kidney and in dose response manner (except in kidney), but no time response (except in plasma). The MEL residue in organ tissue was below the safe level of 50 ?g mL-1 in blood or 50 ?g kg-1 in tissues proposed by the US FSIS when MEL in diet was lower (2 mg kg-1). The MEL in tissues was eliminated by withdrawal MEL from diets. The elimination half-life of MEL was from 3.2 to 6.6 h, and the clearance time, when MEL residue concentration under limit detection, was from 18.0 to 31.4 h. |
topic |
melamine broiler deposition elimination |
url |
http://www.sciencedirect.com/science/article/pii/S1671292712607883 |
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