Mexicanolide-Type Limonoids from the Roots of Trichilia sinensis

Mexicanolide-Type Limonoids from the Roots of Trichilia sinensis

Four new mexicanolide-type limonoids 1–4, along with two known limonoids 5–6, were isolated from the ethanolic extracts of roots of the Traditional Chinese Medicine Trichilia sinensis. Their structures were unambiguously determined by analysis of spectroscopic data, including 1D and 2D NMR as well a...

Full description

Bibliographic Details
Main Authors: Shou-Bai Liu, Wen-Li Mei, Hui-Qin Chen, Zhi-Kai Guo, Hao-Fu Dai, Zhu-Nian Wang
Format: Article
Language:English
Published: MDPI AG 2016-08-01
Series:Molecules
Subjects:
Trichilia sinensis
meliaceae
limonoids
mexicanolide-type
AChE inhibitory activity
Online Access:http://www.mdpi.com/1420-3049/21/9/1152
id doaj-377469c1120842269385b72e0bcaeef0
record_format Article
spelling doaj-377469c1120842269385b72e0bcaeef02020-11-24T23:01:08ZengMDPI AGMolecules1420-30492016-08-01219115210.3390/molecules21091152molecules21091152Mexicanolide-Type Limonoids from the Roots of Trichilia sinensisShou-Bai Liu0Wen-Li Mei1Hui-Qin Chen2Zhi-Kai Guo3Hao-Fu Dai4Zhu-Nian Wang5Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, ChinaKey Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaKey Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaKey Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaKey Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaTropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, ChinaFour new mexicanolide-type limonoids 1–4, along with two known limonoids 5–6, were isolated from the ethanolic extracts of roots of the Traditional Chinese Medicine Trichilia sinensis. Their structures were unambiguously determined by analysis of spectroscopic data, including 1D and 2D NMR as well as MS, and by comparison with literature data. In addition, the acetylcholinesterase (AChE) inhibitory activity of compounds 1–6 was evaluated by the Ellman method. All these compounds showed weak AChE inhibitory activity, with the inhibition percentages ranging from 18.5% to 27.8%.http://www.mdpi.com/1420-3049/21/9/1152Trichilia sinensismeliaceaelimonoidsmexicanolide-typeAChE inhibitory activity
collection DOAJ
language English
format Article
sources DOAJ
author Shou-Bai Liu
Wen-Li Mei
Hui-Qin Chen
Zhi-Kai Guo
Hao-Fu Dai
Zhu-Nian Wang
spellingShingle Shou-Bai Liu
Wen-Li Mei
Hui-Qin Chen
Zhi-Kai Guo
Hao-Fu Dai
Zhu-Nian Wang
Mexicanolide-Type Limonoids from the Roots of Trichilia sinensis
Molecules
Trichilia sinensis
meliaceae
limonoids
mexicanolide-type
AChE inhibitory activity
author_facet Shou-Bai Liu
Wen-Li Mei
Hui-Qin Chen
Zhi-Kai Guo
Hao-Fu Dai
Zhu-Nian Wang
author_sort Shou-Bai Liu
title Mexicanolide-Type Limonoids from the Roots of Trichilia sinensis
title_short Mexicanolide-Type Limonoids from the Roots of Trichilia sinensis
title_full Mexicanolide-Type Limonoids from the Roots of Trichilia sinensis
title_fullStr Mexicanolide-Type Limonoids from the Roots of Trichilia sinensis
title_full_unstemmed Mexicanolide-Type Limonoids from the Roots of Trichilia sinensis
title_sort mexicanolide-type limonoids from the roots of trichilia sinensis
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2016-08-01
description Four new mexicanolide-type limonoids 1–4, along with two known limonoids 5–6, were isolated from the ethanolic extracts of roots of the Traditional Chinese Medicine Trichilia sinensis. Their structures were unambiguously determined by analysis of spectroscopic data, including 1D and 2D NMR as well as MS, and by comparison with literature data. In addition, the acetylcholinesterase (AChE) inhibitory activity of compounds 1–6 was evaluated by the Ellman method. All these compounds showed weak AChE inhibitory activity, with the inhibition percentages ranging from 18.5% to 27.8%.
topic Trichilia sinensis
meliaceae
limonoids
mexicanolide-type
AChE inhibitory activity
url http://www.mdpi.com/1420-3049/21/9/1152
work_keys_str_mv AT shoubailiu mexicanolidetypelimonoidsfromtherootsoftrichiliasinensis
AT wenlimei mexicanolidetypelimonoidsfromtherootsoftrichiliasinensis
AT huiqinchen mexicanolidetypelimonoidsfromtherootsoftrichiliasinensis
AT zhikaiguo mexicanolidetypelimonoidsfromtherootsoftrichiliasinensis
AT haofudai mexicanolidetypelimonoidsfromtherootsoftrichiliasinensis
AT zhunianwang mexicanolidetypelimonoidsfromtherootsoftrichiliasinensis
_version_ 1725640624792666112

Similar Items