Variant of plasmablastic microlymphoma in Castleman disease: a case report and review of the literature
Castleman disease (CD) is a rare lymphoproliferative disorder also known as angiofollicular lymph node hyperplasia or giant lymph node hyperplasia. CD can be unicentric CD (UCD) or multicentric CD (MCD). MCD affects more than one group of lymph nodes and/or lymphoid tissues and it is frequently ass...
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doaj-3783bd66b55041b5a5c27aa5236d7ec72020-11-25T03:41:06ZengPAGEPress PublicationsItalian Journal of Medicine1877-93441877-93522018-12-0112410.4081/itjm.2018.1063Variant of plasmablastic microlymphoma in Castleman disease: a case report and review of the literatureNathan Artom0Marcello Brignone1Luca Paris2Anna Lisa Garlaschelli3Marina Cavaliere4Gian Luca Michelis5Claudia Venturino6Silvia Ardoino7Ezio Venturino8Paola Gnerre9Rodolfo Tassara10Department of Internal Medicine, San Paolo Hospital, SavonaDepartment of Internal Medicine, San Paolo Hospital, SavonaDepartment of Internal Medicine, San Paolo Hospital, SavonaDepartment of Internal Medicine, San Paolo Hospital, SavonaDepartment of Internal Medicine, San Paolo Hospital, SavonaDepartment of Internal Medicine, San Paolo Hospital, SavonaDepartment of Internal Medicine, San Paolo Hospital, SavonaDepartment of Clinical Pathology, San Paolo Hospital, SavonaDepartment of Clinical Pathology, San Paolo Hospital, SavonaDepartment of Internal Medicine, San Paolo Hospital, SavonaDepartment of Internal Medicine, San Paolo Hospital, Savona Castleman disease (CD) is a rare lymphoproliferative disorder also known as angiofollicular lymph node hyperplasia or giant lymph node hyperplasia. CD can be unicentric CD (UCD) or multicentric CD (MCD). MCD affects more than one group of lymph nodes and/or lymphoid tissues and it is frequently associated with HIV and human herpes virus 8 (HHV-8) infections and, in contrast with UCD, it often results in systemic symptoms, such as fever, fatigue, anemia, inflammatory syndrome. HHV- 8-associated MCD recognizes HHV-8 as an etiopathogenetic agent and occurs generally in HIV-positive subjects. Our report describes an HHV-8 positive Castleman disease with plasmablastic microlymphoma occurring in a 51-year-old HIV seronegative woman, with a previous history of HBV infection and Kaposi’s sarcoma, who presented elevated procalcitonin levels during the acute phase of CD. https://www.italjmed.org/index.php/ijm/article/view/1063Castleman diseaselymphoproliferative disordermulticentric Castleman disease. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nathan Artom Marcello Brignone Luca Paris Anna Lisa Garlaschelli Marina Cavaliere Gian Luca Michelis Claudia Venturino Silvia Ardoino Ezio Venturino Paola Gnerre Rodolfo Tassara |
spellingShingle |
Nathan Artom Marcello Brignone Luca Paris Anna Lisa Garlaschelli Marina Cavaliere Gian Luca Michelis Claudia Venturino Silvia Ardoino Ezio Venturino Paola Gnerre Rodolfo Tassara Variant of plasmablastic microlymphoma in Castleman disease: a case report and review of the literature Italian Journal of Medicine Castleman disease lymphoproliferative disorder multicentric Castleman disease. |
author_facet |
Nathan Artom Marcello Brignone Luca Paris Anna Lisa Garlaschelli Marina Cavaliere Gian Luca Michelis Claudia Venturino Silvia Ardoino Ezio Venturino Paola Gnerre Rodolfo Tassara |
author_sort |
Nathan Artom |
title |
Variant of plasmablastic microlymphoma in Castleman disease: a case report and review of the literature |
title_short |
Variant of plasmablastic microlymphoma in Castleman disease: a case report and review of the literature |
title_full |
Variant of plasmablastic microlymphoma in Castleman disease: a case report and review of the literature |
title_fullStr |
Variant of plasmablastic microlymphoma in Castleman disease: a case report and review of the literature |
title_full_unstemmed |
Variant of plasmablastic microlymphoma in Castleman disease: a case report and review of the literature |
title_sort |
variant of plasmablastic microlymphoma in castleman disease: a case report and review of the literature |
publisher |
PAGEPress Publications |
series |
Italian Journal of Medicine |
issn |
1877-9344 1877-9352 |
publishDate |
2018-12-01 |
description |
Castleman disease (CD) is a rare lymphoproliferative disorder also known as angiofollicular lymph node hyperplasia or giant lymph node hyperplasia. CD can be unicentric CD (UCD) or multicentric CD (MCD). MCD affects more than one group of lymph nodes and/or lymphoid tissues and it is frequently associated with HIV and human herpes virus 8 (HHV-8) infections and, in contrast with UCD, it often results in systemic symptoms, such as fever, fatigue, anemia, inflammatory syndrome. HHV- 8-associated MCD recognizes HHV-8 as an etiopathogenetic agent and occurs generally in HIV-positive subjects. Our report describes an HHV-8 positive Castleman disease with plasmablastic microlymphoma occurring in a 51-year-old HIV seronegative woman, with a previous history of HBV infection and Kaposi’s sarcoma, who presented elevated procalcitonin levels during the acute phase of CD.
|
topic |
Castleman disease lymphoproliferative disorder multicentric Castleman disease. |
url |
https://www.italjmed.org/index.php/ijm/article/view/1063 |
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