Expedient Approach to the Synthesis of Betrixaban

Expedient Approach to the Synthesis of Betrixaban

A new scalable route to synthesize the factor Xa (FXa) inhibitor betrixaban is disclosed. The product is obtained in a seven-step reaction sequence (in five stages using two one-pot reactions) starting from easily accessible 4-(N,N-dimethylcarbamimidoyl)benzoate. Effective isolation of intermediates...

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Bibliographic Details
Main Authors:	Chada Raji Reddy, Sudam N. Sinare
Format:	Article
Language:	English
Published:	Georg Thieme Verlag KG 2020-07-01
Series:	SynOpen
Subjects:	betrixaban factor xa (fxa) inhibitor anticoagulant one-pot reaction amidation
Online Access:	http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1707267

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