Targeting mTOR by CZ415 Inhibits Head and Neck Squamous Cell Carcinoma Cells

Targeting mTOR by CZ415 Inhibits Head and Neck Squamous Cell Carcinoma Cells

Background/Aims: mTOR is an important therapeutic target for human head and neck squamous cell carcinoma (HNSCC). The current study tested the anti-HNSCC cell activity by a mTOR kinase inhibitor CZ415. Methods: HNSCC cells were treated with CZ415. Cell death was tested by lactate dehydrogenase (LDH)...

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Bibliographic Details
Main Authors: Jing Xie, Quan Li, Xi Ding, Yunyun Gao
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
Hnscc
MTOR
CZ415
Beclin-1
Autophagy
Online Access:https://www.karger.com/Article/FullText/488724

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