Cerebellar atrophy is frequently associated with non-paraneoplastic sensory neuronopathy
Sensory neuronopathies (SN) are peripheral nervous system disorders associated with degeneration of dorsal root ganglion neurons. Despite the evidence of a defective proprioceptive sensory input in SN,the prominent gait and truncal ataxia raises the question of a concomitant involvement of the cereb...
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2011-08-01
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doaj-379e5d2be8d8490ab842e2a06f1fa3a52020-11-24T22:38:15ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42272011-08-0169460260610.1590/S0004-282X2011000500006S0004-282X2011000500006Cerebellar atrophy is frequently associated with non-paraneoplastic sensory neuronopathyAlfredo Damasceno0Marcondes C. França Jr1Fernando Cendes2Anamarli Nucci3Universidade Estadual de CampinasUniversidade Estadual de CampinasUniversidade Estadual de CampinasUniversidade Estadual de CampinasSensory neuronopathies (SN) are peripheral nervous system disorders associated with degeneration of dorsal root ganglion neurons. Despite the evidence of a defective proprioceptive sensory input in SN,the prominent gait and truncal ataxia raises the question of a concomitant involvement of the cerebellum. OBJECTIVE: To evaluate cerebellar atrophy in SN. METHOD: We analyzed MRI-based volumetry of anterior lobe (paleocerebellum) and total cerebellum in patients with non-paraneoplastic chronic SN and compared to age- and gender-matched controls. RESULTS: Cerebellum and anterior lobe MRI volumetry were performed in 20 patients and nine controls. Mean anterior lobe and cerebellar volume were not statistically different. Three patients (15%), however, had an abnormal anterior lobe and cerebellar volume index (values outside 2.5 standard deviations). One of them also had a specific atrophy of the anterior lobe. All these patients had infectious or dysimmune associated SN. CONCLUSION: Cerebellar atrophy is infrequently associated with SN, but can be found in some patients with SN related to infectious or immune mediated conditions. It can be more prominent in the anterior lobe and may contribute to the ataxia seen in these patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000500006&lng=en&tlng=enatrofia cerebelardoença do neurônio sensitivoneuroimagemneuronopatia sensitivavolumetria cerebelar |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alfredo Damasceno Marcondes C. França Jr Fernando Cendes Anamarli Nucci |
spellingShingle |
Alfredo Damasceno Marcondes C. França Jr Fernando Cendes Anamarli Nucci Cerebellar atrophy is frequently associated with non-paraneoplastic sensory neuronopathy Arquivos de Neuro-Psiquiatria atrofia cerebelar doença do neurônio sensitivo neuroimagem neuronopatia sensitiva volumetria cerebelar |
author_facet |
Alfredo Damasceno Marcondes C. França Jr Fernando Cendes Anamarli Nucci |
author_sort |
Alfredo Damasceno |
title |
Cerebellar atrophy is frequently associated with non-paraneoplastic sensory neuronopathy |
title_short |
Cerebellar atrophy is frequently associated with non-paraneoplastic sensory neuronopathy |
title_full |
Cerebellar atrophy is frequently associated with non-paraneoplastic sensory neuronopathy |
title_fullStr |
Cerebellar atrophy is frequently associated with non-paraneoplastic sensory neuronopathy |
title_full_unstemmed |
Cerebellar atrophy is frequently associated with non-paraneoplastic sensory neuronopathy |
title_sort |
cerebellar atrophy is frequently associated with non-paraneoplastic sensory neuronopathy |
publisher |
Academia Brasileira de Neurologia (ABNEURO) |
series |
Arquivos de Neuro-Psiquiatria |
issn |
1678-4227 |
publishDate |
2011-08-01 |
description |
Sensory neuronopathies (SN) are peripheral nervous system disorders associated with degeneration of dorsal root ganglion neurons. Despite the evidence of a defective proprioceptive sensory input in SN,the prominent gait and truncal ataxia raises the question of a concomitant involvement of the cerebellum. OBJECTIVE: To evaluate cerebellar atrophy in SN. METHOD: We analyzed MRI-based volumetry of anterior lobe (paleocerebellum) and total cerebellum in patients with non-paraneoplastic chronic SN and compared to age- and gender-matched controls. RESULTS: Cerebellum and anterior lobe MRI volumetry were performed in 20 patients and nine controls. Mean anterior lobe and cerebellar volume were not statistically different. Three patients (15%), however, had an abnormal anterior lobe and cerebellar volume index (values outside 2.5 standard deviations). One of them also had a specific atrophy of the anterior lobe. All these patients had infectious or dysimmune associated SN. CONCLUSION: Cerebellar atrophy is infrequently associated with SN, but can be found in some patients with SN related to infectious or immune mediated conditions. It can be more prominent in the anterior lobe and may contribute to the ataxia seen in these patients. |
topic |
atrofia cerebelar doença do neurônio sensitivo neuroimagem neuronopatia sensitiva volumetria cerebelar |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000500006&lng=en&tlng=en |
work_keys_str_mv |
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