Antibody Response to Pneumocystis jirovecii
We conducted a prospective pilot study of the serologic responses to overlapping recombinant fragments of the Pneumocystis jirovecii major surface glycoprotein (Msg) in HIV-infected patients with pneumonia due to P. jirovecii and other causes. Similar baseline geometric mean antibody levels to the f...
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Centers for Disease Control and Prevention
2006-08-01
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Online Access: | https://wwwnc.cdc.gov/eid/article/12/8/06-0230_article |
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doaj-379f1adbac1d489eb87489b5bb12bc2e2020-11-24T23:08:02ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592006-08-011281231123710.3201/eid1208.060230Antibody Response to Pneumocystis jiroveciiKieran R. DalyLaurence HuangAlison MorrisJudy KochKristina CrothersLinda LevinShary EiserSupriya SatwahPatrizia ZucchiPeter D. WalzerWe conducted a prospective pilot study of the serologic responses to overlapping recombinant fragments of the Pneumocystis jirovecii major surface glycoprotein (Msg) in HIV-infected patients with pneumonia due to P. jirovecii and other causes. Similar baseline geometric mean antibody levels to the fragments measured by an ELISA were found in both groups. Serum antibodies to MsgC in P. jirovecii patients rose to a peak level 3–4 weeks (p<0.001) after recovery from pneumocystosis; baseline CD4+ count >50 cells/μL and first episode of pneumocystosis were the principal host factors associated with this rise (both p<0.001). Thus, MsgC shows promise as a serologic reagent and should be tested further in clinical and epidemiologic studies.https://wwwnc.cdc.gov/eid/article/12/8/06-0230_articleHuman Immunodeficiency Virus (HIV)Acquired Immune Deficiency Syndrome (AIDS)Pneumocystis pneumoniaPneumocystis jiroveciiRecombinant antigensMajor surface glycoprotein (Msg) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kieran R. Daly Laurence Huang Alison Morris Judy Koch Kristina Crothers Linda Levin Shary Eiser Supriya Satwah Patrizia Zucchi Peter D. Walzer |
spellingShingle |
Kieran R. Daly Laurence Huang Alison Morris Judy Koch Kristina Crothers Linda Levin Shary Eiser Supriya Satwah Patrizia Zucchi Peter D. Walzer Antibody Response to Pneumocystis jirovecii Emerging Infectious Diseases Human Immunodeficiency Virus (HIV) Acquired Immune Deficiency Syndrome (AIDS) Pneumocystis pneumonia Pneumocystis jirovecii Recombinant antigens Major surface glycoprotein (Msg) |
author_facet |
Kieran R. Daly Laurence Huang Alison Morris Judy Koch Kristina Crothers Linda Levin Shary Eiser Supriya Satwah Patrizia Zucchi Peter D. Walzer |
author_sort |
Kieran R. Daly |
title |
Antibody Response to Pneumocystis jirovecii |
title_short |
Antibody Response to Pneumocystis jirovecii |
title_full |
Antibody Response to Pneumocystis jirovecii |
title_fullStr |
Antibody Response to Pneumocystis jirovecii |
title_full_unstemmed |
Antibody Response to Pneumocystis jirovecii |
title_sort |
antibody response to pneumocystis jirovecii |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2006-08-01 |
description |
We conducted a prospective pilot study of the serologic responses to overlapping recombinant fragments of the Pneumocystis jirovecii major surface glycoprotein (Msg) in HIV-infected patients with pneumonia due to P. jirovecii and other causes. Similar baseline geometric mean antibody levels to the fragments measured by an ELISA were found in both groups. Serum antibodies to MsgC in P. jirovecii patients rose to a peak level 3–4 weeks (p<0.001) after recovery from pneumocystosis; baseline CD4+ count >50 cells/μL and first episode of pneumocystosis were the principal host factors associated with this rise (both p<0.001). Thus, MsgC shows promise as a serologic reagent and should be tested further in clinical and epidemiologic studies. |
topic |
Human Immunodeficiency Virus (HIV) Acquired Immune Deficiency Syndrome (AIDS) Pneumocystis pneumonia Pneumocystis jirovecii Recombinant antigens Major surface glycoprotein (Msg) |
url |
https://wwwnc.cdc.gov/eid/article/12/8/06-0230_article |
work_keys_str_mv |
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1725615735967842304 |