Using Local Convolutional Neural Networks for Genomic Prediction
The prediction of breeding values and phenotypes is of central importance for both livestock and crop breeding. In this study, we analyze the use of artificial neural networks (ANN) and, in particular, local convolutional neural networks (LCNN) for genomic prediction, as a region-specific filter cor...
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doaj-37a332f59ca549ddaba9e124e8057dd52020-11-25T04:00:16ZengFrontiers Media S.A.Frontiers in Genetics1664-80212020-11-011110.3389/fgene.2020.561497561497Using Local Convolutional Neural Networks for Genomic PredictionTorsten Pook0Jan Freudenthal1Arthur Korte2Henner Simianer3Animal Breeding and Genetics Group, Department of Animal Sciences, Center for Integrated Breeding Research, University of Goettingen, Göttingen, GermanyCenter for Computational and Theoretical Biology, University of Wuerzburg, Wuerzburg, GermanyCenter for Computational and Theoretical Biology, University of Wuerzburg, Wuerzburg, GermanyAnimal Breeding and Genetics Group, Department of Animal Sciences, Center for Integrated Breeding Research, University of Goettingen, Göttingen, GermanyThe prediction of breeding values and phenotypes is of central importance for both livestock and crop breeding. In this study, we analyze the use of artificial neural networks (ANN) and, in particular, local convolutional neural networks (LCNN) for genomic prediction, as a region-specific filter corresponds much better with our prior genetic knowledge on the genetic architecture of traits than traditional convolutional neural networks. Model performances are evaluated on a simulated maize data panel (n = 10,000; p = 34,595) and real Arabidopsis data (n = 2,039; p = 180,000) for a variety of traits based on their predictive ability. The baseline LCNN, containing one local convolutional layer (kernel size: 10) and two fully connected layers with 64 nodes each, is outperforming commonly proposed ANNs (multi layer perceptrons and convolutional neural networks) for basically all considered traits. For traits with high heritability and large training population as present in the simulated data, LCNN are even outperforming state-of-the-art methods like genomic best linear unbiased prediction (GBLUP), Bayesian models and extended GBLUP, indicated by an increase in predictive ability of up to 24%. However, for small training populations, these state-of-the-art methods outperform all considered ANNs. Nevertheless, the LCNN still outperforms all other considered ANNs by around 10%. Minor improvements to the tested baseline network architecture of the LCNN were obtained by increasing the kernel size and of reducing the stride, whereas the number of subsequent fully connected layers and their node sizes had neglectable impact. Although gains in predictive ability were obtained for large scale data sets by using LCNNs, the practical use of ANNs comes with additional problems, such as the need of genotyping all considered individuals, the lack of estimation of heritability and reliability. Furthermore, breeding values are additive by design, whereas ANN-based estimates are not. However, ANNs also comes with new opportunities, as networks can easily be extended to account for additional inputs (omics, weather etc.) and outputs (multi-trait models), and computing time increases linearly with the number of individuals. With advances in high-throughput phenotyping and cheaper genotyping, ANNs can become a valid alternative for genomic prediction.https://www.frontiersin.org/articles/10.3389/fgene.2020.561497/fullphenotype predictionKerasgenomic selectionselectionbreedingmachine learning |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Torsten Pook Jan Freudenthal Arthur Korte Henner Simianer |
spellingShingle |
Torsten Pook Jan Freudenthal Arthur Korte Henner Simianer Using Local Convolutional Neural Networks for Genomic Prediction Frontiers in Genetics phenotype prediction Keras genomic selection selection breeding machine learning |
author_facet |
Torsten Pook Jan Freudenthal Arthur Korte Henner Simianer |
author_sort |
Torsten Pook |
title |
Using Local Convolutional Neural Networks for Genomic Prediction |
title_short |
Using Local Convolutional Neural Networks for Genomic Prediction |
title_full |
Using Local Convolutional Neural Networks for Genomic Prediction |
title_fullStr |
Using Local Convolutional Neural Networks for Genomic Prediction |
title_full_unstemmed |
Using Local Convolutional Neural Networks for Genomic Prediction |
title_sort |
using local convolutional neural networks for genomic prediction |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Genetics |
issn |
1664-8021 |
publishDate |
2020-11-01 |
description |
The prediction of breeding values and phenotypes is of central importance for both livestock and crop breeding. In this study, we analyze the use of artificial neural networks (ANN) and, in particular, local convolutional neural networks (LCNN) for genomic prediction, as a region-specific filter corresponds much better with our prior genetic knowledge on the genetic architecture of traits than traditional convolutional neural networks. Model performances are evaluated on a simulated maize data panel (n = 10,000; p = 34,595) and real Arabidopsis data (n = 2,039; p = 180,000) for a variety of traits based on their predictive ability. The baseline LCNN, containing one local convolutional layer (kernel size: 10) and two fully connected layers with 64 nodes each, is outperforming commonly proposed ANNs (multi layer perceptrons and convolutional neural networks) for basically all considered traits. For traits with high heritability and large training population as present in the simulated data, LCNN are even outperforming state-of-the-art methods like genomic best linear unbiased prediction (GBLUP), Bayesian models and extended GBLUP, indicated by an increase in predictive ability of up to 24%. However, for small training populations, these state-of-the-art methods outperform all considered ANNs. Nevertheless, the LCNN still outperforms all other considered ANNs by around 10%. Minor improvements to the tested baseline network architecture of the LCNN were obtained by increasing the kernel size and of reducing the stride, whereas the number of subsequent fully connected layers and their node sizes had neglectable impact. Although gains in predictive ability were obtained for large scale data sets by using LCNNs, the practical use of ANNs comes with additional problems, such as the need of genotyping all considered individuals, the lack of estimation of heritability and reliability. Furthermore, breeding values are additive by design, whereas ANN-based estimates are not. However, ANNs also comes with new opportunities, as networks can easily be extended to account for additional inputs (omics, weather etc.) and outputs (multi-trait models), and computing time increases linearly with the number of individuals. With advances in high-throughput phenotyping and cheaper genotyping, ANNs can become a valid alternative for genomic prediction. |
topic |
phenotype prediction Keras genomic selection selection breeding machine learning |
url |
https://www.frontiersin.org/articles/10.3389/fgene.2020.561497/full |
work_keys_str_mv |
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