Mycolates of Mycobacterium tuberculosis modulate the flow of cholesterol for bacillary proliferation in murine macrophages

Mycolates of Mycobacterium tuberculosis modulate the flow of cholesterol for bacillary proliferation in murine macrophages

The differentiation of macrophages into lipid-filled foam cells is a hallmark of the lung granuloma that forms in patients with active tuberculosis (TB). Mycolic acids (MAs), the abundant lipid virulence factors in the cell wall of Mycobacterium tuberculosis (Mtb), can induce this foam phenotype pos...

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Bibliographic Details
Main Authors: Ilke Vermeulen, Mark Baird, Juma Al-Dulayymi, Muriel Smet, Jan Verschoor, Johan Grooten
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Journal of Lipid Research
Subjects:
confocal microscopy
foam cell
infection
lipid droplets
liver X receptor
mycolic acid
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520338487

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http://www.sciencedirect.com/science/article/pii/S0022227520338487

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