Gain of Function of Ion Channel TRPV1 Exacerbates Experimental Colitis by Promoting Dendritic Cell Activation

Gain of Function of Ion Channel TRPV1 Exacerbates Experimental Colitis by Promoting Dendritic Cell Activation

Dysregulated mucosal immunity plays an essential role in the pathophysiology of inflammatory bowel disease (IBD). Transient receptor potential vanilloid 1 (TRPV1) is a Ca2+-permeable ion channel that is implicated in modulating immune responses. However, its role in the pathogenesis of intestinal in...

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Bibliographic Details
Main Authors: Lina Duo, Ting Wu, Ziliang Ke, Linghan Hu, Chaohui Wang, Guigen Teng, Wei Zhang, Weihong Wang, Qing Ge, Yong Yang, Yun Dai
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
TRPV1
gain of function
colitis
dendritic cells
Th17 cells
NFATc2
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120303188

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http://www.sciencedirect.com/science/article/pii/S2162253120303188

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