Value of autoantibody detection for illness assessment in systemic lupus erythematosus patients with refractory thrombocytopenia
Objective: To analyze the value of autoantibody detection for illness assessment in systemic lupus erythematosus patients with refractory thrombocytopenia. Methods: A total of 60 cases of systemic lupus erythematosus (SLE) with refractory thrombocytopenia were the observation group A, 58 cases of...
Main Author: | |
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Format: | Article |
Language: | English |
Published: |
Editorial Board of Journal of Hainan Medical University
2016-07-01
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Series: | Journal of Hainan Medical University |
Subjects: | |
Online Access: | http://www.hnykdxxb.com/PDF/201613/24.pdf |
Summary: | Objective: To analyze the value of autoantibody detection for illness assessment in systemic
lupus erythematosus patients with refractory thrombocytopenia. Methods: A total of 60 cases
of systemic lupus erythematosus (SLE) with refractory thrombocytopenia were the observation
group A, 58 cases of patients with SLE alone were the observation group B, and 66 cases of
healthy people who received physical examination were control group. Peripheral circulating
blood was drawn from research subjects to detect the levels of autoantibody, illness-related
factors, Th17, Th1 and Th2 cytokines, complements, and so on, and then the correlation
between specific antibody positive rate and disease severity in SLE patients with refractory
thrombocytopenia was further analyzed. Results: Anti-RNP antibody, anti-Sm antibody, antiScl-70 antibody, anti-AnuA antibody, anti-His antibody and anti-ds-DNA antibody positive
rates of observation group A were higher than those of observation group B and control group
(P<0.05); sICAM-1, PTM, sCD30L and MCP-1 values of observation group A were higher
than those of observation group B and control group (P<0.05); serum IL-17, IL-23, IFN-
毭, TNF-毩, IL-4, IL-5 and IL-6 values of observation group A were higher than those of
observation group B and control group (P<0.05); serum C1qAg, C3, C4 and CFH values of
observation group A were lower than those of observation group B and control group while
C1qAb value was higher than that of observation group B and control group (P<0.05); anti-Sm
antibody and anti-ds-DNA antibody positive rates of SLE patients were positively correlated
with serum sICAM-1, PTM, sCD30L, MCP-1, IL-17, IL-23, IFN-毭, TNF-α, IL-4, IL-5, IL-6
and C1qAb values, and negatively correlated with C1qAg, C3, C4 and CFH values (P<0.05).
Conclusions: Specific autoantibody positive rates are high in systemic lupus erythematosus
patients with refractory thrombocytopenia, have direct correlation with the disease severity
and can be used as the reliable indexes of long-term clinical treatment guidance and prognosis
judgment. |
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ISSN: | 1007-1237 1007-1237 |