Value of autoantibody detection for illness assessment in systemic lupus erythematosus patients with refractory thrombocytopenia

• Main Author: Xiao-Liang Wu
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-07-01
• Series: Journal of Hainan Medical University
• Subjects: Systemic lupus erythematosus; Refractory thrombocytopenia; Autoantibody detection
• Online Access: http://www.hnykdxxb.com/PDF/201613/24.pdf

Objective: To analyze the value of autoantibody detection for illness assessment in systemic lupus erythematosus patients with refractory thrombocytopenia. Methods: A total of 60 cases of systemic lupus erythematosus (SLE) with refractory thrombocytopenia were the observation group A, 58 cases of patients with SLE alone were the observation group B, and 66 cases of healthy people who received physical examination were control group. Peripheral circulating blood was drawn from research subjects to detect the levels of autoantibody, illness-related factors, Th17, Th1 and Th2 cytokines, complements, and so on, and then the correlation between specific antibody positive rate and disease severity in SLE patients with refractory thrombocytopenia was further analyzed. Results: Anti-RNP antibody, anti-Sm antibody, antiScl-70 antibody, anti-AnuA antibody, anti-His antibody and anti-ds-DNA antibody positive rates of observation group A were higher than those of observation group B and control group (P<0.05); sICAM-1, PTM, sCD30L and MCP-1 values of observation group A were higher than those of observation group B and control group (P<0.05); serum IL-17, IL-23, IFN- 毭, TNF-毩, IL-4, IL-5 and IL-6 values of observation group A were higher than those of observation group B and control group (P<0.05); serum C1qAg, C3, C4 and CFH values of observation group A were lower than those of observation group B and control group while C1qAb value was higher than that of observation group B and control group (P<0.05); anti-Sm antibody and anti-ds-DNA antibody positive rates of SLE patients were positively correlated with serum sICAM-1, PTM, sCD30L, MCP-1, IL-17, IL-23, IFN-毭, TNF-α, IL-4, IL-5, IL-6 and C1qAb values, and negatively correlated with C1qAg, C3, C4 and CFH values (P<0.05). Conclusions: Specific autoantibody positive rates are high in systemic lupus erythematosus patients with refractory thrombocytopenia, have direct correlation with the disease severity and can be used as the reliable indexes of long-term clinical treatment guidance and prognosis judgment.