Impact of pneumococcal vaccines use on invasive pneumococcal disease in Nunavik (Quebec) from 1997 to 2010
Background: In 2000, an outbreak of severe pneumonia caused by a virulent clone of serotype 1 Streptococcus pneumoniae was detected in the Nunavik region of Quebec. A mass immunization campaign was implemented in the spring of 2002, targeting persons ≥5 years of age and using the 23-valent pneumococ...
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doaj-37dbdd69eb5a46f5b2909bba71b368992020-11-25T00:43:11ZengTaylor & Francis GroupInternational Journal of Circumpolar Health2242-39822014-01-017301610.3402/ijch.v73.2269122691Impact of pneumococcal vaccines use on invasive pneumococcal disease in Nunavik (Quebec) from 1997 to 2010Jean-Baptiste Le Meur0Brigitte Lefebvre1Jean-François Proulx2Serge Déry3Jacques Pépin4Philippe De Wals5 Quebec Heart and Lung Institute Research Centre, Quebec City, Canada Quebec Public Health Laboratory (Laboratoire de santé publique du Québec), Quebec National Institute of Public Health (Institut national de santé publique du Québec), Ste-Anne-de-Bellevue, Canada Public Health Directorate, Nunavik Regional Board of Health and Social Services, Kuujjuaq, Canada Public Health Directorate, Nunavik Regional Board of Health and Social Services, Kuujjuaq, Canada Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Canada Quebec Heart and Lung Institute Research Centre, Quebec City, CanadaBackground: In 2000, an outbreak of severe pneumonia caused by a virulent clone of serotype 1 Streptococcus pneumoniae was detected in the Nunavik region of Quebec. A mass immunization campaign was implemented in the spring of 2002, targeting persons ≥5 years of age and using the 23-valent pneumococcal polysaccharide vaccine (PPSV23). At the same time, the 7-valent pneumococcal conjugate vaccine (PCV7) was introduced into the routine immunization programme of infants, with catch-up for children up to 4 years of age. Objectives: To describe the epidemiology of invasive pneumococcal disease (IPD) in relation to PPSV23 and PCV7 use. Study design and methods: Retrospective analysis of IPD cases identified by the Quebec public health laboratory during the period 1997–2010. Results: A total of 82 IPD cases were identified during the study period. In adults, serotype 1 incidence decreased following the 2002 PPSV23 mass campaign but breakthrough cases continued to occur. Following PCV7 use in children, there was a decrease in the incidence of vaccine-type IPD and replacement by other serotypes in adults. In children, a marked decrease in the annual incidence of serotypes included in PCV7 was observed following PCV7 introduction: 162/100,000 in 1997–2001 vs. 10/100,000 in 2004–2010 (p<0.01). Concomitantly, the incidence of IPD caused by serotypes not included in PCV7 increased from 29/100,000 to 109/100,000 (p=0.11). Conclusion: The mass immunization campaign using the PPSV23 in 2002 and the introduction of PCV7 for the routine immunization of infants induced important modifications in the epidemiology of IPD. IPD rates in Nunavik remain much higher than in the southern part of the province both in children and adults. More effective pneumococcal vaccines are needed to eliminate geographic disparities in IPD risk.www.circumpolarhealthjournal.net/index.php/ijch/article/download/22691/pdf_1immunizationepidemiologyStreptococcus pneumoniapaediatric vaccineInuit |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jean-Baptiste Le Meur Brigitte Lefebvre Jean-François Proulx Serge Déry Jacques Pépin Philippe De Wals |
spellingShingle |
Jean-Baptiste Le Meur Brigitte Lefebvre Jean-François Proulx Serge Déry Jacques Pépin Philippe De Wals Impact of pneumococcal vaccines use on invasive pneumococcal disease in Nunavik (Quebec) from 1997 to 2010 International Journal of Circumpolar Health immunization epidemiology Streptococcus pneumonia paediatric vaccine Inuit |
author_facet |
Jean-Baptiste Le Meur Brigitte Lefebvre Jean-François Proulx Serge Déry Jacques Pépin Philippe De Wals |
author_sort |
Jean-Baptiste Le Meur |
title |
Impact of pneumococcal vaccines use on invasive pneumococcal disease in Nunavik (Quebec) from 1997 to 2010 |
title_short |
Impact of pneumococcal vaccines use on invasive pneumococcal disease in Nunavik (Quebec) from 1997 to 2010 |
title_full |
Impact of pneumococcal vaccines use on invasive pneumococcal disease in Nunavik (Quebec) from 1997 to 2010 |
title_fullStr |
Impact of pneumococcal vaccines use on invasive pneumococcal disease in Nunavik (Quebec) from 1997 to 2010 |
title_full_unstemmed |
Impact of pneumococcal vaccines use on invasive pneumococcal disease in Nunavik (Quebec) from 1997 to 2010 |
title_sort |
impact of pneumococcal vaccines use on invasive pneumococcal disease in nunavik (quebec) from 1997 to 2010 |
publisher |
Taylor & Francis Group |
series |
International Journal of Circumpolar Health |
issn |
2242-3982 |
publishDate |
2014-01-01 |
description |
Background: In 2000, an outbreak of severe pneumonia caused by a virulent clone of serotype 1 Streptococcus pneumoniae was detected in the Nunavik region of Quebec. A mass immunization campaign was implemented in the spring of 2002, targeting persons ≥5 years of age and using the 23-valent pneumococcal polysaccharide vaccine (PPSV23). At the same time, the 7-valent pneumococcal conjugate vaccine (PCV7) was introduced into the routine immunization programme of infants, with catch-up for children up to 4 years of age. Objectives: To describe the epidemiology of invasive pneumococcal disease (IPD) in relation to PPSV23 and PCV7 use. Study design and methods: Retrospective analysis of IPD cases identified by the Quebec public health laboratory during the period 1997–2010. Results: A total of 82 IPD cases were identified during the study period. In adults, serotype 1 incidence decreased following the 2002 PPSV23 mass campaign but breakthrough cases continued to occur. Following PCV7 use in children, there was a decrease in the incidence of vaccine-type IPD and replacement by other serotypes in adults. In children, a marked decrease in the annual incidence of serotypes included in PCV7 was observed following PCV7 introduction: 162/100,000 in 1997–2001 vs. 10/100,000 in 2004–2010 (p<0.01). Concomitantly, the incidence of IPD caused by serotypes not included in PCV7 increased from 29/100,000 to 109/100,000 (p=0.11). Conclusion: The mass immunization campaign using the PPSV23 in 2002 and the introduction of PCV7 for the routine immunization of infants induced important modifications in the epidemiology of IPD. IPD rates in Nunavik remain much higher than in the southern part of the province both in children and adults. More effective pneumococcal vaccines are needed to eliminate geographic disparities in IPD risk. |
topic |
immunization epidemiology Streptococcus pneumonia paediatric vaccine Inuit |
url |
http://www.circumpolarhealthjournal.net/index.php/ijch/article/download/22691/pdf_1 |
work_keys_str_mv |
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