Reduced Frequency of Ipsilateral Express Saccades in Cervical Dystonia: Probing the Nigro-Tectal Pathway

• Main Authors: Rebecca B. Beck, Simone L. Kneafsey, Shruti Narasimham, Sean O'Riordan, Tadashi Isa, Michael Hutchinson, Richard B. Reilly
• Format: Article
• Language: English
• Published: Ubiquity Press 2018-11-01
• Series: Tremor and Other Hyperkinetic Movements
• Subjects: Neurology; Cervical dystonia; Hyperkinetic movements; Ipsilateral Express Saccades; Nigro-Tectal Pathway; Patients; Electro-oculography; Superior colliculus
• Online Access: https://tremorjournal.org/index.php/tremor/article/view/592
• ISSN: 2160-8288; 2160-8288

Background: Cervical dystonia is a hyperkinetic movement disorder of unknown cause. Symptoms of cervical dystonia have been induced in animals in which the integrity of the nigro-tectal pathway is disrupted, resulting in reduced inhibition of the deep layers of the superior colliculus. This same pathway is believed to play a critical role in saccade generation, particularly visually guided, express saccades. It was hypothesized that individuals with cervical dystonia would present with a higher frequency of express saccades and more directional errors. Methods: Eight individuals with cervical dystonia and 11 age- and sex-matched control participants performed three saccadic paradigms: pro-saccade, gap, and anti-saccade (120 trials per task). Eye movements were recorded using electro-oculography. Results: Mean saccadic reaction times were slower in the cervical dystonia group (only statistically significant in the anti-saccade task, F(1, 35) 5 4.76, p 5 0.036); participants with cervical dystonia produced fewer directional errors (mean 14% vs. 22%) in the anti-saccade task; and had similar frequencies of express saccades in the gap task relative to our control population (chi-square 5 1.13, p 5 0.287). All cervical dystonia participants had lower frequencies of express saccades ipsilateral to their dystonic side (the side to which their head turns), (chi-square 5 3.57, p 5 0.059). Discussion: The finding of slower saccadic reaction times in cervical dystonia does not support the concept of reduced inhibition in the nigro-tectal pathway. Further research is required to confirm the observed relationship between the lateralization of lower frequencies of express saccades and direction of head rotation in cervical dystonia.