All-Optical Planar Polymer Waveguide-Based Biosensor Chip Designed for Smartphone-Assisted Detection of Vitamin D
An all-optical plasmonic sensor platform designed for smartphones based on planar-optical waveguide structures integrated in a polymer chip is reported for the first time. To demonstrate the applicability of the sensor system for biosensing purposes, the detection of 25-hydroxyvitamin D (25OHD) in h...
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2020-11-01
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doaj-37e63ff9658f4b5bb4f0552831946a122020-11-28T00:00:50ZengMDPI AGSensors1424-82202020-11-01206771677110.3390/s20236771All-Optical Planar Polymer Waveguide-Based Biosensor Chip Designed for Smartphone-Assisted Detection of Vitamin DJohanna-Gabriela Walter0Lourdes S. M. Alwis1Bernhard Roth2Kort Bremer3Institute of Technical Chemistry, Leibniz University of Hannover, 30167 Hannover, GermanySchool of Engineering and the Built Environment, Edinburgh Napier University, Edinburgh EH10 5DT, UKCluster of Excellence PhoenixD, (Photonics, Optics, and Engineering—Innovation Across Disciplines), 30167 Hannover, GermanyCluster of Excellence PhoenixD, (Photonics, Optics, and Engineering—Innovation Across Disciplines), 30167 Hannover, GermanyAn all-optical plasmonic sensor platform designed for smartphones based on planar-optical waveguide structures integrated in a polymer chip is reported for the first time. To demonstrate the applicability of the sensor system for biosensing purposes, the detection of 25-hydroxyvitamin D (25OHD) in human serum samples using an AuNP-enhanced aptamer-based assay was demonstrated. With the aid of the developed assay sensitivity of 0.752 pixel/nM was achieved for 25OHD concentrations ranging from 0–100 nM. The waveguide structure of the sensor enables miniaturisation and parallelisation, thus, demonstrates the potential for simultaneous detection of various analytes including biomarkers. The entire optical arrangement can be integrated into a single polymer chip which allows for large scale and cost-efficient sensor fabrication. The broad utilization and access of smartphone electronics make the proposed design most attractive for its wider use in lab-on-chip applications.https://www.mdpi.com/1424-8220/20/23/6771surface plasmon resonancebiosensoraptamersvitamin Doptical waveguideintegrated optics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Johanna-Gabriela Walter Lourdes S. M. Alwis Bernhard Roth Kort Bremer |
spellingShingle |
Johanna-Gabriela Walter Lourdes S. M. Alwis Bernhard Roth Kort Bremer All-Optical Planar Polymer Waveguide-Based Biosensor Chip Designed for Smartphone-Assisted Detection of Vitamin D Sensors surface plasmon resonance biosensor aptamers vitamin D optical waveguide integrated optics |
author_facet |
Johanna-Gabriela Walter Lourdes S. M. Alwis Bernhard Roth Kort Bremer |
author_sort |
Johanna-Gabriela Walter |
title |
All-Optical Planar Polymer Waveguide-Based Biosensor Chip Designed for Smartphone-Assisted Detection of Vitamin D |
title_short |
All-Optical Planar Polymer Waveguide-Based Biosensor Chip Designed for Smartphone-Assisted Detection of Vitamin D |
title_full |
All-Optical Planar Polymer Waveguide-Based Biosensor Chip Designed for Smartphone-Assisted Detection of Vitamin D |
title_fullStr |
All-Optical Planar Polymer Waveguide-Based Biosensor Chip Designed for Smartphone-Assisted Detection of Vitamin D |
title_full_unstemmed |
All-Optical Planar Polymer Waveguide-Based Biosensor Chip Designed for Smartphone-Assisted Detection of Vitamin D |
title_sort |
all-optical planar polymer waveguide-based biosensor chip designed for smartphone-assisted detection of vitamin d |
publisher |
MDPI AG |
series |
Sensors |
issn |
1424-8220 |
publishDate |
2020-11-01 |
description |
An all-optical plasmonic sensor platform designed for smartphones based on planar-optical waveguide structures integrated in a polymer chip is reported for the first time. To demonstrate the applicability of the sensor system for biosensing purposes, the detection of 25-hydroxyvitamin D (25OHD) in human serum samples using an AuNP-enhanced aptamer-based assay was demonstrated. With the aid of the developed assay sensitivity of 0.752 pixel/nM was achieved for 25OHD concentrations ranging from 0–100 nM. The waveguide structure of the sensor enables miniaturisation and parallelisation, thus, demonstrates the potential for simultaneous detection of various analytes including biomarkers. The entire optical arrangement can be integrated into a single polymer chip which allows for large scale and cost-efficient sensor fabrication. The broad utilization and access of smartphone electronics make the proposed design most attractive for its wider use in lab-on-chip applications. |
topic |
surface plasmon resonance biosensor aptamers vitamin D optical waveguide integrated optics |
url |
https://www.mdpi.com/1424-8220/20/23/6771 |
work_keys_str_mv |
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