Controlled Release of 18-β-Glycyrrhetinic Acid from Core-Shell Nanoparticles: Effects on Cytotoxicity and Intracellular Concentration in HepG2 Cell Line

Controlled Release of 18-β-Glycyrrhetinic Acid from Core-Shell Nanoparticles: Effects on Cytotoxicity and Intracellular Concentration in HepG2 Cell Line

18β-glycyrrhetinic acid (GA) is a pentacyclic triterpene with promising hepatoprotective and anti-Hepatocellular carcinoma effects. GA low water solubility however reduces its biodistribution and bioavailability, limiting its applications in biomedicine. In this work we used core-shell NPs made of P...

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Bibliographic Details
Main Authors: Giuseppina Nocca, Giuseppe D’Avenio, Adriana Amalfitano, Laura Chronopoulou, Alvaro Mordente, Cleofe Palocci, Mauro Grigioni
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Materials
Subjects:
nanoparticles
drug delivery
ECIS
cytotoxicity
Online Access:https://www.mdpi.com/1996-1944/14/14/3893

Internet

https://www.mdpi.com/1996-1944/14/14/3893

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