Vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological study
Abstract Background Vaspin is a novel anti-inflammatory adipokine associated with cardiovascular (CV) disease and inflammation in chronic inflammatory conditions different from axial spondyloarthritis (axSpA). Given the high incidence of CV disease (mainly due to accelerated atherosclerosis) exhibit...
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2021-04-01
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Series: | Arthritis Research & Therapy |
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Online Access: | https://doi.org/10.1186/s13075-021-02499-7 |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Javier Rueda-Gotor Raquel López-Mejías Sara Remuzgo-Martínez Verónica Pulito-Cueto Alfonso Corrales Leticia Lera-Gómez Virginia Portilla Íñigo González-Mazón Ricardo Blanco Rosa Expósito Cristina Mata Javier Llorca Vanesa Hernández-Hernández Carlos Rodríguez-Lozano Nuria Barbarroja Rafaela Ortega Castro Esther Vicente Cristina Fernández-Carballido María Paz Martínez-Vidal David Castro-Corredor Joaquín Anino-Fernández Diana Peiteado Chamaida Plasencia-Rodríguez Eva Galíndez-Agirregoikoa María Luz García-Vivar Oreste Gualillo Juan Carlos Quevedo-Abeledo Santos Castañeda Iván Ferraz-Amaro Miguel Á. González-Gay Fernanda Genre |
spellingShingle |
Javier Rueda-Gotor Raquel López-Mejías Sara Remuzgo-Martínez Verónica Pulito-Cueto Alfonso Corrales Leticia Lera-Gómez Virginia Portilla Íñigo González-Mazón Ricardo Blanco Rosa Expósito Cristina Mata Javier Llorca Vanesa Hernández-Hernández Carlos Rodríguez-Lozano Nuria Barbarroja Rafaela Ortega Castro Esther Vicente Cristina Fernández-Carballido María Paz Martínez-Vidal David Castro-Corredor Joaquín Anino-Fernández Diana Peiteado Chamaida Plasencia-Rodríguez Eva Galíndez-Agirregoikoa María Luz García-Vivar Oreste Gualillo Juan Carlos Quevedo-Abeledo Santos Castañeda Iván Ferraz-Amaro Miguel Á. González-Gay Fernanda Genre Vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological study Arthritis Research & Therapy Vaspin Axial spondyloarthritis Biomarker Subclinical atherosclerosis Cardiovascular risk Polymorphism |
author_facet |
Javier Rueda-Gotor Raquel López-Mejías Sara Remuzgo-Martínez Verónica Pulito-Cueto Alfonso Corrales Leticia Lera-Gómez Virginia Portilla Íñigo González-Mazón Ricardo Blanco Rosa Expósito Cristina Mata Javier Llorca Vanesa Hernández-Hernández Carlos Rodríguez-Lozano Nuria Barbarroja Rafaela Ortega Castro Esther Vicente Cristina Fernández-Carballido María Paz Martínez-Vidal David Castro-Corredor Joaquín Anino-Fernández Diana Peiteado Chamaida Plasencia-Rodríguez Eva Galíndez-Agirregoikoa María Luz García-Vivar Oreste Gualillo Juan Carlos Quevedo-Abeledo Santos Castañeda Iván Ferraz-Amaro Miguel Á. González-Gay Fernanda Genre |
author_sort |
Javier Rueda-Gotor |
title |
Vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological study |
title_short |
Vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological study |
title_full |
Vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological study |
title_fullStr |
Vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological study |
title_full_unstemmed |
Vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological study |
title_sort |
vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological study |
publisher |
BMC |
series |
Arthritis Research & Therapy |
issn |
1478-6362 |
publishDate |
2021-04-01 |
description |
Abstract Background Vaspin is a novel anti-inflammatory adipokine associated with cardiovascular (CV) disease and inflammation in chronic inflammatory conditions different from axial spondyloarthritis (axSpA). Given the high incidence of CV disease (mainly due to accelerated atherosclerosis) exhibited by axSpA patients, we wondered if vaspin could also be a key molecule in this process. However, data on the role of vaspin regarding atherosclerotic disease in the context of axSpA is scarce. For this reason, we aimed to evaluate the implication of vaspin, at the genetic and serological level, in subclinical atherosclerosis and CV risk in axSpA. Methods This study included 510 patients diagnosed with axSpA. Carotid ultrasound (US) was performed to evaluate the presence of subclinical atherosclerosis. Three vaspin gene variants (rs2236242, rs7159023, and rs35262691) were genotyped by TaqMan probes. Serum vaspin levels were assessed by enzyme-linked immunosorbent assay. Statistical analysis was performed using STATA® v.11.1. Results Serum vaspin levels were significantly higher in female patients than in males and also in obese patients when compared to those with normal weight (p < 0.05). At the genetic level, we disclosed that the minor allele of rs2236242 (A) was associated with lower serum vaspin levels in axSpA, while the rs7159023 minor allele (A) was linked to higher serum levels (p < 0.05). When the three polymorphisms assessed were combined conforming haplotypes, we disclosed that the TGC haplotype related to high serum levels of vaspin (p = 0.01). However, no statistically significant association was observed between vaspin and markers of subclinical atherosclerosis, both at the genetic and serological level. Conclusions Our results revealed that vaspin is linked to CV risk factors that may influence on the atherosclerotic process in axSpA. Additionally, we disclosed that serum vaspin concentration is genetically modulated in a large cohort of patients with axSpA. |
topic |
Vaspin Axial spondyloarthritis Biomarker Subclinical atherosclerosis Cardiovascular risk Polymorphism |
url |
https://doi.org/10.1186/s13075-021-02499-7 |
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doaj-37eebbcda0594b05aafabd6baf9220612021-04-18T11:50:02ZengBMCArthritis Research & Therapy1478-63622021-04-012311910.1186/s13075-021-02499-7Vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological studyJavier Rueda-Gotor0Raquel López-Mejías1Sara Remuzgo-Martínez2Verónica Pulito-Cueto3Alfonso Corrales4Leticia Lera-Gómez5Virginia Portilla6Íñigo González-Mazón7Ricardo Blanco8Rosa Expósito9Cristina Mata10Javier Llorca11Vanesa Hernández-Hernández12Carlos Rodríguez-Lozano13Nuria Barbarroja14Rafaela Ortega Castro15Esther Vicente16Cristina Fernández-Carballido17María Paz Martínez-Vidal18David Castro-Corredor19Joaquín Anino-Fernández20Diana Peiteado21Chamaida Plasencia-Rodríguez22Eva Galíndez-Agirregoikoa23María Luz García-Vivar24Oreste Gualillo25Juan Carlos Quevedo-Abeledo26Santos Castañeda27Iván Ferraz-Amaro28Miguel Á. González-Gay29Fernanda Genre30Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Diseases of the Musculoskeletal System, IDIVAL, Hospital Universitario Marqués de ValdecillaResearch Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Diseases of the Musculoskeletal System, IDIVAL, Hospital Universitario Marqués de ValdecillaResearch Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Diseases of the Musculoskeletal System, IDIVAL, Hospital Universitario Marqués de ValdecillaResearch Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Diseases of the Musculoskeletal System, IDIVAL, Hospital Universitario Marqués de ValdecillaResearch Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Diseases of the Musculoskeletal System, IDIVAL, Hospital Universitario Marqués de ValdecillaResearch Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Diseases of the Musculoskeletal System, IDIVAL, Hospital Universitario Marqués de ValdecillaResearch Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Diseases of the Musculoskeletal System, IDIVAL, Hospital Universitario Marqués de ValdecillaResearch Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Diseases of the Musculoskeletal System, IDIVAL, Hospital Universitario Marqués de ValdecillaResearch Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Diseases of the Musculoskeletal System, IDIVAL, Hospital Universitario Marqués de ValdecillaRheumatology Division, Hospital Comarcal de LaredoRheumatology Division, Hospital Comarcal de LaredoDepartment of Epidemiology and Computational Biology, School of Medicine, University of Cantabria and CIBERESPRheumatology Division, Hospital Universitario de CanariasRheumatology Division, Hospital Universitario de Gran Canaria Dr. NegrínRheumatology Division, Hospital Reina Sofía, Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC), University of CordobaRheumatology Division, Hospital Reina Sofía, Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC), University of CordobaRheumatology Division, Hospital Universitario de La Princesa, IIS-PrincesaRheumatology Division, Hospital Universitario de San JuanRheumatology Division, Hospital General Universitario de AlicanteRheumatology Division, Hospital General Universitario de Ciudad RealRheumatology Division, Hospital General Universitario de Ciudad RealRheumatology Division, Hospital Universitario La Paz-IdiPazRheumatology Division, Hospital Universitario La Paz-IdiPazRheumatology Division, Hospital Universitario BasurtoRheumatology Division, Hospital Universitario BasurtoSERGAS and IDIS, NEIRID Lab, Research Laboratory 9, Santiago University Clinical HospitalRheumatology Division, Hospital Universitario de Gran Canaria Dr. NegrínRheumatology Division, Hospital Universitario de La Princesa, IIS-PrincesaRheumatology Division, Hospital Universitario de CanariasResearch Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Diseases of the Musculoskeletal System, IDIVAL, Hospital Universitario Marqués de ValdecillaResearch Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Diseases of the Musculoskeletal System, IDIVAL, Hospital Universitario Marqués de ValdecillaAbstract Background Vaspin is a novel anti-inflammatory adipokine associated with cardiovascular (CV) disease and inflammation in chronic inflammatory conditions different from axial spondyloarthritis (axSpA). Given the high incidence of CV disease (mainly due to accelerated atherosclerosis) exhibited by axSpA patients, we wondered if vaspin could also be a key molecule in this process. However, data on the role of vaspin regarding atherosclerotic disease in the context of axSpA is scarce. For this reason, we aimed to evaluate the implication of vaspin, at the genetic and serological level, in subclinical atherosclerosis and CV risk in axSpA. Methods This study included 510 patients diagnosed with axSpA. Carotid ultrasound (US) was performed to evaluate the presence of subclinical atherosclerosis. Three vaspin gene variants (rs2236242, rs7159023, and rs35262691) were genotyped by TaqMan probes. Serum vaspin levels were assessed by enzyme-linked immunosorbent assay. Statistical analysis was performed using STATA® v.11.1. Results Serum vaspin levels were significantly higher in female patients than in males and also in obese patients when compared to those with normal weight (p < 0.05). At the genetic level, we disclosed that the minor allele of rs2236242 (A) was associated with lower serum vaspin levels in axSpA, while the rs7159023 minor allele (A) was linked to higher serum levels (p < 0.05). When the three polymorphisms assessed were combined conforming haplotypes, we disclosed that the TGC haplotype related to high serum levels of vaspin (p = 0.01). However, no statistically significant association was observed between vaspin and markers of subclinical atherosclerosis, both at the genetic and serological level. Conclusions Our results revealed that vaspin is linked to CV risk factors that may influence on the atherosclerotic process in axSpA. Additionally, we disclosed that serum vaspin concentration is genetically modulated in a large cohort of patients with axSpA.https://doi.org/10.1186/s13075-021-02499-7VaspinAxial spondyloarthritisBiomarkerSubclinical atherosclerosisCardiovascular riskPolymorphism |