Chronic low alcohol intake during pregnancy programs sex-specific cardiovascular deficits in rats
Abstract Background Exposure to an adverse environment in early life can have lifelong consequences for risk of cardiovascular disease. Maternal alcohol (ethanol) intake is common and associated with a variety of harmful effects to the fetus. However, examining the effects on the cardiovascular syst...
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doaj-37f1a55aee554663af795e52be34c30e2020-11-25T03:09:13ZengBMCBiology of Sex Differences2042-64102019-04-0110111410.1186/s13293-019-0235-9Chronic low alcohol intake during pregnancy programs sex-specific cardiovascular deficits in ratsSarah L. Walton0Melissa Tjongue1Marianne Tare2Edmund Kwok3Megan Probyn4Helena C. Parkington5John F. Bertram6Karen M. Moritz7Kate M. Denton8Cardiovascular Disease Program, Monash Biomedicine Discovery InstituteCardiovascular Disease Program, Monash Biomedicine Discovery InstituteDepartment of Physiology, Monash UniversityCardiovascular Disease Program, Monash Biomedicine Discovery InstituteSchool of Biomedical Sciences, The University of QueenslandDepartment of Physiology, Monash UniversityDepartment of Anatomy and Developmental Biology, Monash UniversitySchool of Biomedical Sciences, The University of QueenslandCardiovascular Disease Program, Monash Biomedicine Discovery InstituteAbstract Background Exposure to an adverse environment in early life can have lifelong consequences for risk of cardiovascular disease. Maternal alcohol (ethanol) intake is common and associated with a variety of harmful effects to the fetus. However, examining the effects on the cardiovascular system in adult offspring has largely been neglected. The objectives of this study were to investigate the influence of chronic, low ethanol consumption throughout pregnancy on blood pressure, vascular reactivity and wall stiffness, all key determinants of cardiovascular health, in both male and female rat offspring. Methods Female Sprague-Dawley rats were fed an ad libitum liquid diet ± 6% vol/vol ethanol throughout pregnancy. Male and female offspring were studied at 12 months of age. Arterial pressure, heart rate and locomotor activity were measured over 7 days via radiotelemetry. Renal lobar arteries were isolated and studied using wire and pressure myography. Results Basal mean arterial pressure in female ethanol-exposed rats was reduced by ~ 5–6 mmHg compared to control female offspring, whereas arterial pressure was unaffected in male offspring. Ethanol-exposed offspring had an attenuated pressor response to an acute restraint stress, with this effect most evident in females. Renal artery function was not affected by prenatal ethanol exposure. Conclusions We show for the first time that low level chronic maternal alcohol intake during pregnancy influences arterial pressure in adult offspring in the absence of fetal growth restriction.http://link.springer.com/article/10.1186/s13293-019-0235-9Fetal programmingAlcoholBlood pressureVascular function |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sarah L. Walton Melissa Tjongue Marianne Tare Edmund Kwok Megan Probyn Helena C. Parkington John F. Bertram Karen M. Moritz Kate M. Denton |
spellingShingle |
Sarah L. Walton Melissa Tjongue Marianne Tare Edmund Kwok Megan Probyn Helena C. Parkington John F. Bertram Karen M. Moritz Kate M. Denton Chronic low alcohol intake during pregnancy programs sex-specific cardiovascular deficits in rats Biology of Sex Differences Fetal programming Alcohol Blood pressure Vascular function |
author_facet |
Sarah L. Walton Melissa Tjongue Marianne Tare Edmund Kwok Megan Probyn Helena C. Parkington John F. Bertram Karen M. Moritz Kate M. Denton |
author_sort |
Sarah L. Walton |
title |
Chronic low alcohol intake during pregnancy programs sex-specific cardiovascular deficits in rats |
title_short |
Chronic low alcohol intake during pregnancy programs sex-specific cardiovascular deficits in rats |
title_full |
Chronic low alcohol intake during pregnancy programs sex-specific cardiovascular deficits in rats |
title_fullStr |
Chronic low alcohol intake during pregnancy programs sex-specific cardiovascular deficits in rats |
title_full_unstemmed |
Chronic low alcohol intake during pregnancy programs sex-specific cardiovascular deficits in rats |
title_sort |
chronic low alcohol intake during pregnancy programs sex-specific cardiovascular deficits in rats |
publisher |
BMC |
series |
Biology of Sex Differences |
issn |
2042-6410 |
publishDate |
2019-04-01 |
description |
Abstract Background Exposure to an adverse environment in early life can have lifelong consequences for risk of cardiovascular disease. Maternal alcohol (ethanol) intake is common and associated with a variety of harmful effects to the fetus. However, examining the effects on the cardiovascular system in adult offspring has largely been neglected. The objectives of this study were to investigate the influence of chronic, low ethanol consumption throughout pregnancy on blood pressure, vascular reactivity and wall stiffness, all key determinants of cardiovascular health, in both male and female rat offspring. Methods Female Sprague-Dawley rats were fed an ad libitum liquid diet ± 6% vol/vol ethanol throughout pregnancy. Male and female offspring were studied at 12 months of age. Arterial pressure, heart rate and locomotor activity were measured over 7 days via radiotelemetry. Renal lobar arteries were isolated and studied using wire and pressure myography. Results Basal mean arterial pressure in female ethanol-exposed rats was reduced by ~ 5–6 mmHg compared to control female offspring, whereas arterial pressure was unaffected in male offspring. Ethanol-exposed offspring had an attenuated pressor response to an acute restraint stress, with this effect most evident in females. Renal artery function was not affected by prenatal ethanol exposure. Conclusions We show for the first time that low level chronic maternal alcohol intake during pregnancy influences arterial pressure in adult offspring in the absence of fetal growth restriction. |
topic |
Fetal programming Alcohol Blood pressure Vascular function |
url |
http://link.springer.com/article/10.1186/s13293-019-0235-9 |
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