Association of ghrelin with cardiometabolic risk factors in Iranian adolescents: the CASPIAN-III study
Introduction: Current evidence suggests that ghrelin could contribute to the development of metabolic syndrome (MetS) in adults, but limited experience exists in adolescents. This study aims to explore the association of ghrelin levels with the MetS components among Iranian adolescents. Methods: In...
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Tabriz University of Medical Sciences
2016-09-01
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doaj-37f51d13b0e248e8bae0b4c20319d2cf2020-11-25T00:29:11ZengTabriz University of Medical SciencesJournal of Cardiovascular and Thoracic Research2008-51172008-68302016-09-018310711210.15171/jcvtr.2016.23JCVTR_4059_20160312130909Association of ghrelin with cardiometabolic risk factors in Iranian adolescents: the CASPIAN-III studyRamin Heshmat0Gita Shafiee1Mostafa Qorbani2Fatemeh Azizi-Soleiman3Shirin Djalalinia4Mohammad Esmaeil Motlagh5Gelayol Ardalan6Zeinab Ahadi7Omid Safari8Saeid Safiri9Roya Kelishadi10Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IranChronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IranDepartment of Community Medicine, Alborz University of Medical Sciences, Karaj, IranDepartment of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, IranDevelopment of Research & Technology Center, Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, IranDepartment of Pediatrics, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, IranChronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IranDepartment of Pediatrics, Alborz University of Medical Sciences, Karaj, IranManagerial Epidemiology Research Center, Department of Public Health, School of Nursing and Midwifery, Maragheh University of Medical Sciences, Maragheh, IranDepartment of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, IranIntroduction: Current evidence suggests that ghrelin could contribute to the development of metabolic syndrome (MetS) in adults, but limited experience exists in adolescents. This study aims to explore the association of ghrelin levels with the MetS components among Iranian adolescents. Methods: In this case-control study, 32 adolescents with MetS and 148 healthy controls were selected randomly from the childhood and Adolescence Surveillance and Prevention of Adult Non communicable disease (CASPIAN-III) study. MetS was defined according to the Adult Treatment Panel III (ATP III) criteria modified for children and adolescents. Anthropometric measures (including body mass index [BMI], waist circumference [WC] and waist to height ratio [WHtR]), blood pressure (BP) and biochemical data (including fasting blood sugar [FBS], triglyceride [TG], high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], total cholesterol [TC] and gerlin) were measured. Results: Total ghrelin level was significantly higher in students without MetS compared to those with MetS (748.89 ± 85.04 vs. 728.72 ± 90.36 [pg/mL]; P < 0.001). Significant negative correlations were seen between ghrelin levels and BMI, WC, WHtR, TG, and TC. Ghrelin had also relatively strong inverse correlations with FBS (r = −0.59, P < 0.001), LDL-C (r = −0.56, P < 0.001), and positive correlation with HDL-C (r = 0.60, P < 0.001). Compared with the children with MetS, in those without MetS, ghrelin was significantly associated with HDL-C and LDL-C. A decreasing trend was observed in the mean ghrelin level across increasing number of MetS components (P for trend <0.001). Conclusion: We observed a relationship between ghrelin concentration and MetS components in adolescents.http://jcvtr.tbzmed.ac.ir/PDF/JCVTR-8-107.pdfCardiovascular Risk FactorsAdolescentMetabolic SyndromeGhrelin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ramin Heshmat Gita Shafiee Mostafa Qorbani Fatemeh Azizi-Soleiman Shirin Djalalinia Mohammad Esmaeil Motlagh Gelayol Ardalan Zeinab Ahadi Omid Safari Saeid Safiri Roya Kelishadi |
spellingShingle |
Ramin Heshmat Gita Shafiee Mostafa Qorbani Fatemeh Azizi-Soleiman Shirin Djalalinia Mohammad Esmaeil Motlagh Gelayol Ardalan Zeinab Ahadi Omid Safari Saeid Safiri Roya Kelishadi Association of ghrelin with cardiometabolic risk factors in Iranian adolescents: the CASPIAN-III study Journal of Cardiovascular and Thoracic Research Cardiovascular Risk Factors Adolescent Metabolic Syndrome Ghrelin |
author_facet |
Ramin Heshmat Gita Shafiee Mostafa Qorbani Fatemeh Azizi-Soleiman Shirin Djalalinia Mohammad Esmaeil Motlagh Gelayol Ardalan Zeinab Ahadi Omid Safari Saeid Safiri Roya Kelishadi |
author_sort |
Ramin Heshmat |
title |
Association of ghrelin with cardiometabolic risk factors in Iranian adolescents: the CASPIAN-III study |
title_short |
Association of ghrelin with cardiometabolic risk factors in Iranian adolescents: the CASPIAN-III study |
title_full |
Association of ghrelin with cardiometabolic risk factors in Iranian adolescents: the CASPIAN-III study |
title_fullStr |
Association of ghrelin with cardiometabolic risk factors in Iranian adolescents: the CASPIAN-III study |
title_full_unstemmed |
Association of ghrelin with cardiometabolic risk factors in Iranian adolescents: the CASPIAN-III study |
title_sort |
association of ghrelin with cardiometabolic risk factors in iranian adolescents: the caspian-iii study |
publisher |
Tabriz University of Medical Sciences |
series |
Journal of Cardiovascular and Thoracic Research |
issn |
2008-5117 2008-6830 |
publishDate |
2016-09-01 |
description |
Introduction: Current evidence suggests that ghrelin could contribute to the development of metabolic syndrome (MetS) in adults, but limited experience exists in adolescents. This study aims to explore the association of ghrelin levels with the MetS components among Iranian adolescents.
Methods: In this case-control study, 32 adolescents with MetS and 148 healthy controls were selected randomly from the childhood and Adolescence Surveillance and Prevention of Adult Non communicable disease (CASPIAN-III) study. MetS was defined according to the Adult Treatment Panel III (ATP III) criteria modified for children and adolescents. Anthropometric measures (including body mass index [BMI], waist circumference [WC] and waist to height ratio [WHtR]), blood pressure (BP) and biochemical data (including fasting blood sugar [FBS], triglyceride [TG], high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], total cholesterol [TC] and gerlin) were measured.
Results: Total ghrelin level was significantly higher in students without MetS compared to those with MetS (748.89 ± 85.04 vs. 728.72 ± 90.36 [pg/mL]; P < 0.001). Significant negative correlations were seen between ghrelin levels and BMI, WC, WHtR, TG, and TC. Ghrelin had also relatively strong inverse correlations with FBS (r = −0.59, P < 0.001), LDL-C (r = −0.56, P < 0.001), and positive correlation with HDL-C (r = 0.60, P < 0.001). Compared with the children with MetS, in those without MetS, ghrelin was significantly associated with HDL-C and LDL-C. A decreasing trend was observed in the mean ghrelin level across increasing number of MetS components (P for trend <0.001).
Conclusion: We observed a relationship between ghrelin concentration and MetS components in adolescents. |
topic |
Cardiovascular Risk Factors Adolescent Metabolic Syndrome Ghrelin |
url |
http://jcvtr.tbzmed.ac.ir/PDF/JCVTR-8-107.pdf |
work_keys_str_mv |
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