Clinical characteristics of Lewy body dementia in Chinese memory clinics
Abstract Background Lewy body dementia (LBD), consisting of dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD), is the second most common type of neurodegenerative dementia in older people. The current study aimed to investigate the clinical characteristics of LBD in Chinese memo...
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doaj-37f53817ec1b41ea9438b4cfadc040d92021-04-04T11:24:02ZengBMCBMC Neurology1471-23772021-03-0121111110.1186/s12883-021-02169-wClinical characteristics of Lewy body dementia in Chinese memory clinicsJinghuan Gan0Shuai Liu1Xiaodan Wang2Zhihong Shi3Lu Shen4Xudong Li5Qihao Guo6Junliang Yuan7Nan Zhang8Yong You9Yang Lv10Dongming Zheng11Yong Ji12China Lewy Body Disease Collaborative AllianceDepartment of neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological DiseasesDepartment of Neurology, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebrovascular and of Neurodegenerative Diseases, Tianjin Dementia InstituteDepartment of Neurology, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebrovascular and of Neurodegenerative Diseases, Tianjin Dementia InstituteDepartment of Neurology, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebrovascular and of Neurodegenerative Diseases, Tianjin Dementia InstituteDepartment of Neurology, Xiangya Hospital, Central South UniversityDepartment of neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological DiseasesDepartment of Gerontology, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital)Department of Neurology, Tianjin Medical University General HospitalDepartment of Neurology, Second Affiliated Hospital of Hainan Medical UniversityDepartment of Geriatrics, the First Affiliated Hospital of Chongqing Medical UniversityDepartment of Neurology, Shengjing Hospital Affiliated to China Medical UniversityDepartment of neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological DiseasesAbstract Background Lewy body dementia (LBD), consisting of dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD), is the second most common type of neurodegenerative dementia in older people. The current study aimed to investigate the clinical characteristics of LBD in Chinese memory clinics. Methods A total of 8405 dementia medical records were reviewed, revealing 455 patients with LBD. Demographic data, neuropsychological scores, and the scale for Medial Temporal lobe Atrophy (MTA) were then analyzed from nine memory clinics in the China Lewy Body Disease Collaborative Alliance. Results The clinical proportion of LBD among the subjects and among all dementia types was 5.4% (4.9–5.9%) and 7.3% (6.7–8.0%), respectively, with a mean onset age of 68.6 ± 8.4 years. Patients with DLB comprised 5.6% (n = 348, age of onset 69.1 ± 8.3), while PDD comprised 1.7% (n = 107, age of onset 66.7 ± 8.8) of all dementia cases. There were slightly more males than females with DLB (n = 177, 50.9%) and PDD (n = 62, 57.9%). Patients with DLB had a poorer performance compared to those with PDD on the MMSE (16.8 ± 7.1 vs. 19.5 ± 5.7, p = 0.001), the MoCA (11.4 ± 6.6 vs. 14.0 ± 5.8, p<0.001), the CDR (1.8 ± 0.7 vs. 1.6 ± 0.7, p = 0.002), and the MTA (1.8 ± 0.7 vs. 1.2 ± 0.6, p = 0.002). Diagnostic differences for LBD exist among the centers; their reported proportions of those with DLB ranged from 0.7 to 11.4 and those with PDD ranged from 0.0 to 2.9%. Conclusions Variations of diagnoses exists in different regions and the clinical proportion of LBD is likely to be underestimated in China and other regions.https://doi.org/10.1186/s12883-021-02169-wLewy body dementiaDementia with Lewy bodiesParkinson’s disease dementiaPrevalenceGenderMolecular image |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jinghuan Gan Shuai Liu Xiaodan Wang Zhihong Shi Lu Shen Xudong Li Qihao Guo Junliang Yuan Nan Zhang Yong You Yang Lv Dongming Zheng Yong Ji China Lewy Body Disease Collaborative Alliance |
spellingShingle |
Jinghuan Gan Shuai Liu Xiaodan Wang Zhihong Shi Lu Shen Xudong Li Qihao Guo Junliang Yuan Nan Zhang Yong You Yang Lv Dongming Zheng Yong Ji China Lewy Body Disease Collaborative Alliance Clinical characteristics of Lewy body dementia in Chinese memory clinics BMC Neurology Lewy body dementia Dementia with Lewy bodies Parkinson’s disease dementia Prevalence Gender Molecular image |
author_facet |
Jinghuan Gan Shuai Liu Xiaodan Wang Zhihong Shi Lu Shen Xudong Li Qihao Guo Junliang Yuan Nan Zhang Yong You Yang Lv Dongming Zheng Yong Ji China Lewy Body Disease Collaborative Alliance |
author_sort |
Jinghuan Gan |
title |
Clinical characteristics of Lewy body dementia in Chinese memory clinics |
title_short |
Clinical characteristics of Lewy body dementia in Chinese memory clinics |
title_full |
Clinical characteristics of Lewy body dementia in Chinese memory clinics |
title_fullStr |
Clinical characteristics of Lewy body dementia in Chinese memory clinics |
title_full_unstemmed |
Clinical characteristics of Lewy body dementia in Chinese memory clinics |
title_sort |
clinical characteristics of lewy body dementia in chinese memory clinics |
publisher |
BMC |
series |
BMC Neurology |
issn |
1471-2377 |
publishDate |
2021-03-01 |
description |
Abstract Background Lewy body dementia (LBD), consisting of dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD), is the second most common type of neurodegenerative dementia in older people. The current study aimed to investigate the clinical characteristics of LBD in Chinese memory clinics. Methods A total of 8405 dementia medical records were reviewed, revealing 455 patients with LBD. Demographic data, neuropsychological scores, and the scale for Medial Temporal lobe Atrophy (MTA) were then analyzed from nine memory clinics in the China Lewy Body Disease Collaborative Alliance. Results The clinical proportion of LBD among the subjects and among all dementia types was 5.4% (4.9–5.9%) and 7.3% (6.7–8.0%), respectively, with a mean onset age of 68.6 ± 8.4 years. Patients with DLB comprised 5.6% (n = 348, age of onset 69.1 ± 8.3), while PDD comprised 1.7% (n = 107, age of onset 66.7 ± 8.8) of all dementia cases. There were slightly more males than females with DLB (n = 177, 50.9%) and PDD (n = 62, 57.9%). Patients with DLB had a poorer performance compared to those with PDD on the MMSE (16.8 ± 7.1 vs. 19.5 ± 5.7, p = 0.001), the MoCA (11.4 ± 6.6 vs. 14.0 ± 5.8, p<0.001), the CDR (1.8 ± 0.7 vs. 1.6 ± 0.7, p = 0.002), and the MTA (1.8 ± 0.7 vs. 1.2 ± 0.6, p = 0.002). Diagnostic differences for LBD exist among the centers; their reported proportions of those with DLB ranged from 0.7 to 11.4 and those with PDD ranged from 0.0 to 2.9%. Conclusions Variations of diagnoses exists in different regions and the clinical proportion of LBD is likely to be underestimated in China and other regions. |
topic |
Lewy body dementia Dementia with Lewy bodies Parkinson’s disease dementia Prevalence Gender Molecular image |
url |
https://doi.org/10.1186/s12883-021-02169-w |
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