Lack of Gut Secretory Immunoglobulin A in Memory B-Cell Dysfunction-Associated Disorders: A Possible Gut-Spleen Axis

Lack of Gut Secretory Immunoglobulin A in Memory B-Cell Dysfunction-Associated Disorders: A Possible Gut-Spleen Axis

Background: B-1a B cells and gut secretory IgA (SIgA) are absent in asplenic mice. Human immunoglobulin M (IgM) memory B cells, which are functionally equivalent to mouse B-1a B cells, are reduced after splenectomy.Objective: To demonstrate whether IgM memory B cells are necessary for generating IgA...

Full description

Bibliographic Details
Main Authors: Rita Carsetti, Antonio Di Sabatino, Maria Manuela Rosado, Simona Cascioli, Eva Piano Mortari, Cinzia Milito, Ola Grimsholm, Alaitz Aranburu, Ezio Giorda, Francesco Paolo Tinozzi, Federica Pulvirenti, Giuseppe Donato, Francesco Morini, Pietro Bagolan, Gino Roberto Corazza, Isabella Quinti
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
common variable immune deficiency
gut mucosal immunology
plasma cell
splenectomy
transmembrane activator and calcium-modulator and cyclophilin ligand interactor
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02937/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02937/full

Similar Items