Lack of Gut Secretory Immunoglobulin A in Memory B-Cell Dysfunction-Associated Disorders: A Possible Gut-Spleen Axis
Background: B-1a B cells and gut secretory IgA (SIgA) are absent in asplenic mice. Human immunoglobulin M (IgM) memory B cells, which are functionally equivalent to mouse B-1a B cells, are reduced after splenectomy.Objective: To demonstrate whether IgM memory B cells are necessary for generating IgA...
Main Authors: | Rita Carsetti, Antonio Di Sabatino, Maria Manuela Rosado, Simona Cascioli, Eva Piano Mortari, Cinzia Milito, Ola Grimsholm, Alaitz Aranburu, Ezio Giorda, Francesco Paolo Tinozzi, Federica Pulvirenti, Giuseppe Donato, Francesco Morini, Pietro Bagolan, Gino Roberto Corazza, Isabella Quinti |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-01-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.02937/full |
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