Association of maternal folate status in the second trimester of pregnancy with the risk of gestational diabetes mellitus
Abstract Interest in the high folate status of pregnant women has increased due to its role in the prevention of neural tube defects (NTDs). The effect of increased red blood cell (RBC) folate status during the second trimester of pregnancy on gestational diabetes mellitus (GDM) remains unclear. We...
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doaj-37fd435589574bdabaf6beb12233a1632020-11-24T21:50:44ZengWileyFood Science & Nutrition2048-71772019-11-017113759376510.1002/fsn3.1235Association of maternal folate status in the second trimester of pregnancy with the risk of gestational diabetes mellitusKaipeng Xie0Pengfei Xu1Ziyi Fu2Xiaohong Gu3Hui Li4Xianwei Cui5Lianghui You6Lijun Zhu7Chenbo Ji8Xirong Guo9Women's Hospital of Nanjing Medical University The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University Nanjing Maternity and Child Health Care Hospital Nanjing ChinaWomen's Hospital of Nanjing Medical University The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University Nanjing Maternity and Child Health Care Hospital Nanjing ChinaWomen's Hospital of Nanjing Medical University The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University Nanjing Maternity and Child Health Care Hospital Nanjing ChinaWomen's Hospital of Nanjing Medical University The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University Nanjing Maternity and Child Health Care Hospital Nanjing ChinaWomen's Hospital of Nanjing Medical University The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University Nanjing Maternity and Child Health Care Hospital Nanjing ChinaWomen's Hospital of Nanjing Medical University The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University Nanjing Maternity and Child Health Care Hospital Nanjing ChinaWomen's Hospital of Nanjing Medical University The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University Nanjing Maternity and Child Health Care Hospital Nanjing ChinaWomen's Hospital of Nanjing Medical University The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University Nanjing Maternity and Child Health Care Hospital Nanjing ChinaWomen's Hospital of Nanjing Medical University The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University Nanjing Maternity and Child Health Care Hospital Nanjing ChinaWomen's Hospital of Nanjing Medical University The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University Nanjing Maternity and Child Health Care Hospital Nanjing ChinaAbstract Interest in the high folate status of pregnant women has increased due to its role in the prevention of neural tube defects (NTDs). The effect of increased red blood cell (RBC) folate status during the second trimester of pregnancy on gestational diabetes mellitus (GDM) remains unclear. We measured RBC folate concentrations by competitive protein‐binding assay and obtained clinical information from electronic medical records. Logistic regression analysis was used to explore the associations of RBC folate concentrations with risks of gestational diabetes mellitus (GDM). We further assessed the potential nonlinear relations between continuous log‐transformed RBC folate concentrations and GDM risk by using the restricted cubic splines. We observed high RBC folate concentrations in GDM patients compared to control group [median (interquartile range, IQR), GDM vs. controls: 1,554.03 (1,240.54–1,949.99) vs. 1,478.83 (1,124.60–1,865.71) nmol/L, p = .001]. Notably, high folate concentrations were significantly associated with an increased risk of GDM [RR per 1‐SD increase: 1.16 (1.03, 1.30), p = .012] after adjustment for maternal age, parity, and body mass index (BMI) at enrollment. In the restricted cubic spline model, a test of the null hypothesis of the linear relationship was rejected (p = .001). Our study firstly showed that maternal RBC folate concentrations during the second trimester of pregnancy increase the risk of GDM in a Chinese population. Further randomized clinical trials (RCTs) are warranted to confirm the adverse effect.https://doi.org/10.1002/fsn3.1235gestational diabetes mellitusred blood cell folaterisk |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kaipeng Xie Pengfei Xu Ziyi Fu Xiaohong Gu Hui Li Xianwei Cui Lianghui You Lijun Zhu Chenbo Ji Xirong Guo |
spellingShingle |
Kaipeng Xie Pengfei Xu Ziyi Fu Xiaohong Gu Hui Li Xianwei Cui Lianghui You Lijun Zhu Chenbo Ji Xirong Guo Association of maternal folate status in the second trimester of pregnancy with the risk of gestational diabetes mellitus Food Science & Nutrition gestational diabetes mellitus red blood cell folate risk |
author_facet |
Kaipeng Xie Pengfei Xu Ziyi Fu Xiaohong Gu Hui Li Xianwei Cui Lianghui You Lijun Zhu Chenbo Ji Xirong Guo |
author_sort |
Kaipeng Xie |
title |
Association of maternal folate status in the second trimester of pregnancy with the risk of gestational diabetes mellitus |
title_short |
Association of maternal folate status in the second trimester of pregnancy with the risk of gestational diabetes mellitus |
title_full |
Association of maternal folate status in the second trimester of pregnancy with the risk of gestational diabetes mellitus |
title_fullStr |
Association of maternal folate status in the second trimester of pregnancy with the risk of gestational diabetes mellitus |
title_full_unstemmed |
Association of maternal folate status in the second trimester of pregnancy with the risk of gestational diabetes mellitus |
title_sort |
association of maternal folate status in the second trimester of pregnancy with the risk of gestational diabetes mellitus |
publisher |
Wiley |
series |
Food Science & Nutrition |
issn |
2048-7177 |
publishDate |
2019-11-01 |
description |
Abstract Interest in the high folate status of pregnant women has increased due to its role in the prevention of neural tube defects (NTDs). The effect of increased red blood cell (RBC) folate status during the second trimester of pregnancy on gestational diabetes mellitus (GDM) remains unclear. We measured RBC folate concentrations by competitive protein‐binding assay and obtained clinical information from electronic medical records. Logistic regression analysis was used to explore the associations of RBC folate concentrations with risks of gestational diabetes mellitus (GDM). We further assessed the potential nonlinear relations between continuous log‐transformed RBC folate concentrations and GDM risk by using the restricted cubic splines. We observed high RBC folate concentrations in GDM patients compared to control group [median (interquartile range, IQR), GDM vs. controls: 1,554.03 (1,240.54–1,949.99) vs. 1,478.83 (1,124.60–1,865.71) nmol/L, p = .001]. Notably, high folate concentrations were significantly associated with an increased risk of GDM [RR per 1‐SD increase: 1.16 (1.03, 1.30), p = .012] after adjustment for maternal age, parity, and body mass index (BMI) at enrollment. In the restricted cubic spline model, a test of the null hypothesis of the linear relationship was rejected (p = .001). Our study firstly showed that maternal RBC folate concentrations during the second trimester of pregnancy increase the risk of GDM in a Chinese population. Further randomized clinical trials (RCTs) are warranted to confirm the adverse effect. |
topic |
gestational diabetes mellitus red blood cell folate risk |
url |
https://doi.org/10.1002/fsn3.1235 |
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