Comparative study between Dexmedetomidine and Ondansteron for prevention of post spinal shivering. A randomized controlled trial
Abstract Background Regional anesthesia could affect the homeostatic system functions resulting frequently in perioperative hypothermia and consequently shivering. The objective of this trial was to evaluate the efficacy of dexmedetomidine and ondansetron to reduce the incidence and severity of shiv...
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doaj-3802b8eb23414dbda1bc864c8188e2eb2020-11-25T03:44:57ZengBMCBMC Anesthesiology1471-22532018-11-011811810.1186/s12871-018-0640-3Comparative study between Dexmedetomidine and Ondansteron for prevention of post spinal shivering. A randomized controlled trialJoseph Makram Botros0Atef Mohamed Sayed Mahmoud1Safaa Gaber Ragab2Mohammed Awad Alsaeid Ahmed3Hany Maher Salib Roushdy4Hany Mahmoud Yassin5Maged Labib Bolus6Abeer Shaban Goda7Department of Anesthesia, Fayoum UniversityDepartment of Anesthesia, Fayoum UniversityDepartment of Anesthesia, Fayoum UniversityDepartment of Anesthesia, Fayoum UniversityDepartment of Anesthesia, Ain Shams UniversityDepartment of Anesthesia, Fayoum UniversityDepartment of Anesthesia, Fayoum UniversityDepartment of Anesthesia, Fayoum UniversityAbstract Background Regional anesthesia could affect the homeostatic system functions resulting frequently in perioperative hypothermia and consequently shivering. The objective of this trial was to evaluate the efficacy of dexmedetomidine and ondansetron to reduce the incidence and severity of shivering after intrathecal blocks. Methods This randomized placebo-controlled trial included 120 patients allocated equally in three groups. All patients were anesthetized by standard intrathecal blocks for surgical procedure at lower half of the body and received one of the study drugs intravenously (IV) according to the group assignments. Group S patients (placebo) were administered saline, Group O (ondansetron) were given 8 mg ondansetron, and Group D (dexmedetomidine) were given 1 μg/kg of dexmedetomidine. Shivering incidence and scores, sedation scores, core body temperature, hemodynamic variables, and incidence of complications (nausea, vomiting, hypotension, bradycardia, over-sedation, and desaturation) were recorded. Results The incidence and 95% confidence interval (95% CI) of shivering in group S 57.5% (42.18–72.82%) was significantly higher than that of both group O 17.5% (5.73–29.27%), P < 0.001 and group D 27.5% (13.66–41.34%), P = 0.012. However, the difference in the incidence of shivering between group O and group D was comparable, P = 0.425. The sedation scores were significantly higher in group D than those of both group S and group O, P < 0.001. Sedation scores between group S and group O were comparable, P = 0.19. Incidences of adverse effects were comparable between the three groups. Conclusion Prophylactic administrations of dexmedetomidine or ondansetron efficiently decrease the incidence and severity of shivering after spinal anesthesia as compared to placebo without significant difference between their efficacies when compared to each other. Trial registration Pan African Clinical Trial Registry (PACTR) under trial number (PACTR201710002706318). 18-10-2017. ‘retrospectively registered’.http://link.springer.com/article/10.1186/s12871-018-0640-3DexmedetomidineIntraoperative hypothermiaOndansetronShiveringSpinal anesthesia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Joseph Makram Botros Atef Mohamed Sayed Mahmoud Safaa Gaber Ragab Mohammed Awad Alsaeid Ahmed Hany Maher Salib Roushdy Hany Mahmoud Yassin Maged Labib Bolus Abeer Shaban Goda |
spellingShingle |
Joseph Makram Botros Atef Mohamed Sayed Mahmoud Safaa Gaber Ragab Mohammed Awad Alsaeid Ahmed Hany Maher Salib Roushdy Hany Mahmoud Yassin Maged Labib Bolus Abeer Shaban Goda Comparative study between Dexmedetomidine and Ondansteron for prevention of post spinal shivering. A randomized controlled trial BMC Anesthesiology Dexmedetomidine Intraoperative hypothermia Ondansetron Shivering Spinal anesthesia |
author_facet |
Joseph Makram Botros Atef Mohamed Sayed Mahmoud Safaa Gaber Ragab Mohammed Awad Alsaeid Ahmed Hany Maher Salib Roushdy Hany Mahmoud Yassin Maged Labib Bolus Abeer Shaban Goda |
author_sort |
Joseph Makram Botros |
title |
Comparative study between Dexmedetomidine and Ondansteron for prevention of post spinal shivering. A randomized controlled trial |
title_short |
Comparative study between Dexmedetomidine and Ondansteron for prevention of post spinal shivering. A randomized controlled trial |
title_full |
Comparative study between Dexmedetomidine and Ondansteron for prevention of post spinal shivering. A randomized controlled trial |
title_fullStr |
Comparative study between Dexmedetomidine and Ondansteron for prevention of post spinal shivering. A randomized controlled trial |
title_full_unstemmed |
Comparative study between Dexmedetomidine and Ondansteron for prevention of post spinal shivering. A randomized controlled trial |
title_sort |
comparative study between dexmedetomidine and ondansteron for prevention of post spinal shivering. a randomized controlled trial |
publisher |
BMC |
series |
BMC Anesthesiology |
issn |
1471-2253 |
publishDate |
2018-11-01 |
description |
Abstract Background Regional anesthesia could affect the homeostatic system functions resulting frequently in perioperative hypothermia and consequently shivering. The objective of this trial was to evaluate the efficacy of dexmedetomidine and ondansetron to reduce the incidence and severity of shivering after intrathecal blocks. Methods This randomized placebo-controlled trial included 120 patients allocated equally in three groups. All patients were anesthetized by standard intrathecal blocks for surgical procedure at lower half of the body and received one of the study drugs intravenously (IV) according to the group assignments. Group S patients (placebo) were administered saline, Group O (ondansetron) were given 8 mg ondansetron, and Group D (dexmedetomidine) were given 1 μg/kg of dexmedetomidine. Shivering incidence and scores, sedation scores, core body temperature, hemodynamic variables, and incidence of complications (nausea, vomiting, hypotension, bradycardia, over-sedation, and desaturation) were recorded. Results The incidence and 95% confidence interval (95% CI) of shivering in group S 57.5% (42.18–72.82%) was significantly higher than that of both group O 17.5% (5.73–29.27%), P < 0.001 and group D 27.5% (13.66–41.34%), P = 0.012. However, the difference in the incidence of shivering between group O and group D was comparable, P = 0.425. The sedation scores were significantly higher in group D than those of both group S and group O, P < 0.001. Sedation scores between group S and group O were comparable, P = 0.19. Incidences of adverse effects were comparable between the three groups. Conclusion Prophylactic administrations of dexmedetomidine or ondansetron efficiently decrease the incidence and severity of shivering after spinal anesthesia as compared to placebo without significant difference between their efficacies when compared to each other. Trial registration Pan African Clinical Trial Registry (PACTR) under trial number (PACTR201710002706318). 18-10-2017. ‘retrospectively registered’. |
topic |
Dexmedetomidine Intraoperative hypothermia Ondansetron Shivering Spinal anesthesia |
url |
http://link.springer.com/article/10.1186/s12871-018-0640-3 |
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