Lessons from the Crystal Structure of the S. aureus Surface Protein Clumping Factor A in Complex With Tefibazumab, an Inhibiting Monoclonal Antibody

Lessons from the Crystal Structure of the S. aureus Surface Protein Clumping Factor A in Complex With Tefibazumab, an Inhibiting Monoclonal Antibody

The Staphylococcus aureus fibrinogen binding MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules), ClfA (clumping factor A) is an important virulence factor in staphylococcal infections and a component of several vaccines currently under clinical evaluation. The mouse monoclo...

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Bibliographic Details
Main Authors: Vannakambadi K. Ganesh, Xiaowen Liang, Joan A. Geoghegan, Ana Luisa V. Cohen, Nagarajan Venugopalan, Timothy J Foster, Magnus Hook
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:EBioMedicine
Subjects:
Staphylococcal infections
Clumping factor A
Fibrinogen
Tefibazumab
Aurexis
Therapeutic mAb
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416304492

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