Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis
Abstract Effective removal or dissolution of large blood clots remains a challenge in clinical treatment of acute thrombo-occlusive diseases. Here we report the development of an intravascular microbubble-mediated sonothrombolysis device for improving thrombolytic rate and thus minimizing the requir...
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2017-06-01
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Online Access: | https://doi.org/10.1038/s41598-017-03492-4 |
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doaj-380f5c38f1464df3b2af21c25b4faad32020-12-08T02:04:01ZengNature Publishing GroupScientific Reports2045-23222017-06-017111010.1038/s41598-017-03492-4Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysisJinwook Kim0Brooks D. Lindsey1Wei-Yi Chang2Xuming Dai3Joseph M. Stavas4Paul A. Dayton5Xiaoning Jiang6Department of Mechanical and Aerospace Engineering, North Carolina State UniversityJoint Department of Biomedical Engineering, University of North Carolina and North Carolina State UniversityDepartment of Mechanical and Aerospace Engineering, North Carolina State UniversityDivision of Cardiology, University of North CarolinaDivision of Vascular and Interventional Radiology, University of North CarolinaJoint Department of Biomedical Engineering, University of North Carolina and North Carolina State UniversityDepartment of Mechanical and Aerospace Engineering, North Carolina State UniversityAbstract Effective removal or dissolution of large blood clots remains a challenge in clinical treatment of acute thrombo-occlusive diseases. Here we report the development of an intravascular microbubble-mediated sonothrombolysis device for improving thrombolytic rate and thus minimizing the required dose of thrombolytic drugs. We hypothesize that a sub-megahertz, forward-looking ultrasound transducer with an integrated microbubble injection tube is more advantageous for efficient thrombolysis by enhancing cavitation-induced microstreaming than the conventional high-frequency, side-looking, catheter-mounted transducers. We developed custom miniaturized transducers and demonstrated that these transducers are able to generate sufficient pressure to induce cavitation of lipid-shelled microbubble contrast agents. Our technology demonstrates a thrombolysis rate of 0.7 ± 0.15 percent mass loss/min in vitro without any use of thrombolytic drugs.https://doi.org/10.1038/s41598-017-03492-4 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jinwook Kim Brooks D. Lindsey Wei-Yi Chang Xuming Dai Joseph M. Stavas Paul A. Dayton Xiaoning Jiang |
spellingShingle |
Jinwook Kim Brooks D. Lindsey Wei-Yi Chang Xuming Dai Joseph M. Stavas Paul A. Dayton Xiaoning Jiang Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis Scientific Reports |
author_facet |
Jinwook Kim Brooks D. Lindsey Wei-Yi Chang Xuming Dai Joseph M. Stavas Paul A. Dayton Xiaoning Jiang |
author_sort |
Jinwook Kim |
title |
Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis |
title_short |
Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis |
title_full |
Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis |
title_fullStr |
Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis |
title_full_unstemmed |
Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis |
title_sort |
intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2017-06-01 |
description |
Abstract Effective removal or dissolution of large blood clots remains a challenge in clinical treatment of acute thrombo-occlusive diseases. Here we report the development of an intravascular microbubble-mediated sonothrombolysis device for improving thrombolytic rate and thus minimizing the required dose of thrombolytic drugs. We hypothesize that a sub-megahertz, forward-looking ultrasound transducer with an integrated microbubble injection tube is more advantageous for efficient thrombolysis by enhancing cavitation-induced microstreaming than the conventional high-frequency, side-looking, catheter-mounted transducers. We developed custom miniaturized transducers and demonstrated that these transducers are able to generate sufficient pressure to induce cavitation of lipid-shelled microbubble contrast agents. Our technology demonstrates a thrombolysis rate of 0.7 ± 0.15 percent mass loss/min in vitro without any use of thrombolytic drugs. |
url |
https://doi.org/10.1038/s41598-017-03492-4 |
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