Statin-Induced Nitric Oxide Signaling: Mechanisms and Therapeutic Implications

In addition to their cholesterol-lowering effects, statins are associated with pleiotropic effects including improvements in heart failure (HF), reduced blood pressure, prevention of the rupture of atherosclerotic plaques and improved angiogenesis. In addition to these cardiovascular benefits, stati...

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Main Authors:	Armita Mahdavi Gorabi, Nasim Kiaie, Saeideh Hajighasemi, Maciej Banach, Peter E. Penson, Tannaz Jamialahmadi, Amirhossein Sahebkar
Format:	Article
Language:	English
Published:	MDPI AG 2019-11-01
Series:	Journal of Clinical Medicine
Subjects:	statin endothelial nitric oxide angiogenesis heart failure atherosclerosis cancer neuroprotection
Online Access:	https://www.mdpi.com/2077-0383/8/12/2051

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spelling	doaj-38182e474b504efaa7c3a966005e23f92020-11-25T00:34:30ZengMDPI AGJournal of Clinical Medicine2077-03832019-11-01812205110.3390/jcm8122051jcm8122051Statin-Induced Nitric Oxide Signaling: Mechanisms and Therapeutic ImplicationsArmita Mahdavi Gorabi0Nasim Kiaie1Saeideh Hajighasemi2Maciej Banach3Peter E. Penson4Tannaz Jamialahmadi5Amirhossein Sahebkar6Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran 1411713138, IranResearch Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran 1411713138, IranDepartment of Medical Biotechnology, Faculty of Paramedicine, Qazvin University of Medical Sciences, Qazvin 1531534199, IranDepartment of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Zeromskiego 113, 93-338 Lodz, PolandSchool of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UKHalal Research Center of IRI, FDA, Tehran 1411713138, IranBiotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 9177948564, IranIn addition to their cholesterol-lowering effects, statins are associated with pleiotropic effects including improvements in heart failure (HF), reduced blood pressure, prevention of the rupture of atherosclerotic plaques and improved angiogenesis. In addition to these cardiovascular benefits, statins have been implicated in the treatment of neurological injuries, cancer, sepsis, and cirrhosis. These cholesterol-independent beneficial effects of statins are predominantly mediated through signaling pathways leading to increased production and bioavailability of nitric oxide (NO). In this review, the mechanistic pathways and therapeutic effects of statin-mediated elevations of NO are described and discussed.https://www.mdpi.com/2077-0383/8/12/2051statinendothelial nitric oxideangiogenesisheart failureatherosclerosiscancerneuroprotection
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Armita Mahdavi Gorabi Nasim Kiaie Saeideh Hajighasemi Maciej Banach Peter E. Penson Tannaz Jamialahmadi Amirhossein Sahebkar
spellingShingle	Armita Mahdavi Gorabi Nasim Kiaie Saeideh Hajighasemi Maciej Banach Peter E. Penson Tannaz Jamialahmadi Amirhossein Sahebkar Statin-Induced Nitric Oxide Signaling: Mechanisms and Therapeutic Implications Journal of Clinical Medicine statin endothelial nitric oxide angiogenesis heart failure atherosclerosis cancer neuroprotection
author_facet	Armita Mahdavi Gorabi Nasim Kiaie Saeideh Hajighasemi Maciej Banach Peter E. Penson Tannaz Jamialahmadi Amirhossein Sahebkar
author_sort	Armita Mahdavi Gorabi
title	Statin-Induced Nitric Oxide Signaling: Mechanisms and Therapeutic Implications
title_short	Statin-Induced Nitric Oxide Signaling: Mechanisms and Therapeutic Implications
title_full	Statin-Induced Nitric Oxide Signaling: Mechanisms and Therapeutic Implications
title_fullStr	Statin-Induced Nitric Oxide Signaling: Mechanisms and Therapeutic Implications
title_full_unstemmed	Statin-Induced Nitric Oxide Signaling: Mechanisms and Therapeutic Implications
title_sort	statin-induced nitric oxide signaling: mechanisms and therapeutic implications
publisher	MDPI AG
series	Journal of Clinical Medicine
issn	2077-0383
publishDate	2019-11-01
description	In addition to their cholesterol-lowering effects, statins are associated with pleiotropic effects including improvements in heart failure (HF), reduced blood pressure, prevention of the rupture of atherosclerotic plaques and improved angiogenesis. In addition to these cardiovascular benefits, statins have been implicated in the treatment of neurological injuries, cancer, sepsis, and cirrhosis. These cholesterol-independent beneficial effects of statins are predominantly mediated through signaling pathways leading to increased production and bioavailability of nitric oxide (NO). In this review, the mechanistic pathways and therapeutic effects of statin-mediated elevations of NO are described and discussed.
topic	statin endothelial nitric oxide angiogenesis heart failure atherosclerosis cancer neuroprotection
url	https://www.mdpi.com/2077-0383/8/12/2051
work_keys_str_mv	AT armitamahdavigorabi statininducednitricoxidesignalingmechanismsandtherapeuticimplications AT nasimkiaie statininducednitricoxidesignalingmechanismsandtherapeuticimplications AT saeidehhajighasemi statininducednitricoxidesignalingmechanismsandtherapeuticimplications AT maciejbanach statininducednitricoxidesignalingmechanismsandtherapeuticimplications AT peterepenson statininducednitricoxidesignalingmechanismsandtherapeuticimplications AT tannazjamialahmadi statininducednitricoxidesignalingmechanismsandtherapeuticimplications AT amirhosseinsahebkar statininducednitricoxidesignalingmechanismsandtherapeuticimplications
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Statin-Induced Nitric Oxide Signaling: Mechanisms and Therapeutic Implications

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