Association of CD28 IVS3 +17T/C Polymorphism with Soluble CD28 in Rheumatoid Arthritis
Objective: Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology in which inflammatory pathology involves T cell activation and the CD28 costimulatory molecule involved in T cell presentation. The gene includes the CD28 IVS3 +17T/C polymorphism that could be associated with suscepti...
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Hindawi Limited
2011-01-01
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| Series: | Disease Markers |
| Online Access: | http://dx.doi.org/10.3233/DMA-2011-0760 |
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doaj-381fb91a157a4aa3abd7c958f43304902020-11-25T00:45:36ZengHindawi LimitedDisease Markers0278-02401875-86302011-01-01301252910.3233/DMA-2011-0760Association of CD28 IVS3 +17T/C Polymorphism with Soluble CD28 in Rheumatoid ArthritisI. Y. Ledezma-Lozano0J. J. Padilla-Martínez1S. D. Leyva-Torres2I. Parra-Rojas3M. G. Ramírez-Dueñas4Ana Laura Pereira-Suárez5H. Rangel-Villalobos6S. L. Ruiz-Quezada7P. E. Sánchez-Hernández8J. F. Muñoz-Valle9Departamento de Biología Molecular y Genómica. Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, MexicoDepartamento de Biología Molecular y Genómica. Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, MexicoDepartment of Rheumatology. Hospital "Valentín Gómez-Farías ISSSTE", Zapopan, Jalisco, MexicoUnidad Académica de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero, MexicoLaboratorio de Inmunología. Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, MexicoLaboratorio de Inmunología. Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, MexicoInstituto de Investigación en Genética Molecular. Centro Universitario de la Ciénega, Universidad de Guadalajara; Ocotlán, Jalisco, MexicoLaboratorio de Biología Molecular, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara; Guadalalajara, Jalisco, MexicoLaboratorio de Inmunología. Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, MexicoDepartamento de Biología Molecular y Genómica. Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, MexicoObjective: Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology in which inflammatory pathology involves T cell activation and the CD28 costimulatory molecule involved in T cell presentation. The gene includes the CD28 IVS3 +17T/C polymorphism that could be associated with susceptibility to RA whereas the soluble concentrations of CD28 (sCD28) could be related to clinical activity.http://dx.doi.org/10.3233/DMA-2011-0760 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
I. Y. Ledezma-Lozano J. J. Padilla-Martínez S. D. Leyva-Torres I. Parra-Rojas M. G. Ramírez-Dueñas Ana Laura Pereira-Suárez H. Rangel-Villalobos S. L. Ruiz-Quezada P. E. Sánchez-Hernández J. F. Muñoz-Valle |
| spellingShingle |
I. Y. Ledezma-Lozano J. J. Padilla-Martínez S. D. Leyva-Torres I. Parra-Rojas M. G. Ramírez-Dueñas Ana Laura Pereira-Suárez H. Rangel-Villalobos S. L. Ruiz-Quezada P. E. Sánchez-Hernández J. F. Muñoz-Valle Association of CD28 IVS3 +17T/C Polymorphism with Soluble CD28 in Rheumatoid Arthritis Disease Markers |
| author_facet |
I. Y. Ledezma-Lozano J. J. Padilla-Martínez S. D. Leyva-Torres I. Parra-Rojas M. G. Ramírez-Dueñas Ana Laura Pereira-Suárez H. Rangel-Villalobos S. L. Ruiz-Quezada P. E. Sánchez-Hernández J. F. Muñoz-Valle |
| author_sort |
I. Y. Ledezma-Lozano |
| title |
Association of CD28 IVS3 +17T/C Polymorphism with Soluble CD28 in Rheumatoid Arthritis |
| title_short |
Association of CD28 IVS3 +17T/C Polymorphism with Soluble CD28 in Rheumatoid Arthritis |
| title_full |
Association of CD28 IVS3 +17T/C Polymorphism with Soluble CD28 in Rheumatoid Arthritis |
| title_fullStr |
Association of CD28 IVS3 +17T/C Polymorphism with Soluble CD28 in Rheumatoid Arthritis |
| title_full_unstemmed |
Association of CD28 IVS3 +17T/C Polymorphism with Soluble CD28 in Rheumatoid Arthritis |
| title_sort |
association of cd28 ivs3 +17t/c polymorphism with soluble cd28 in rheumatoid arthritis |
| publisher |
Hindawi Limited |
| series |
Disease Markers |
| issn |
0278-0240 1875-8630 |
| publishDate |
2011-01-01 |
| description |
Objective: Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology in which inflammatory pathology involves T cell activation and the CD28 costimulatory molecule involved in T cell presentation. The gene includes the CD28 IVS3 +17T/C polymorphism that could be associated with susceptibility to RA whereas the soluble concentrations of CD28 (sCD28) could be related to clinical activity. |
| url |
http://dx.doi.org/10.3233/DMA-2011-0760 |
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