Chronic Hippocampal Abnormalities and Blunted HPA Axis in an Animal Model of Repeated Unpredictable Stress

Chronic Hippocampal Abnormalities and Blunted HPA Axis in an Animal Model of Repeated Unpredictable Stress

Incidence of post-traumatic stress disorder (PTSD) ranges from 3 to 30% in individuals exposed to traumatic events, with the highest prevalence in groups exposed to combat, torture, or rape. To date, only a few FDA approved drugs are available to treat PTSD, which only offer symptomatic relief and v...

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Bibliographic Details
Main Authors: Moustafa Algamal, Joseph O. Ojo, Carlyn P. Lungmus, Phillip Muza, Constance Cammarata, Margaret J. Owens, Benoit C. Mouzon, David M. Diamond, Michael Mullan, Fiona Crawford
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
PTSD
animal model
stress
HPA axis
corticosterone
Online Access:https://www.frontiersin.org/article/10.3389/fnbeh.2018.00150/full

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