Inducible and reversible phenotypes in a novel mouse model of Friedreich’s Ataxia
Friedreich's ataxia (FRDA), the most common inherited ataxia, is caused by recessive mutations that reduce the levels of frataxin (FXN), a mitochondrial iron binding protein. We developed an inducible mouse model of Fxn deficiency that enabled us to control the onset and progression of disease...
Main Authors: | Vijayendran Chandran, Kun Gao, Vivek Swarup, Revital Versano, Hongmei Dong, Maria C Jordan, Daniel H Geschwind |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2017-12-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/30054 |
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