Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation

Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation

Cardiac dysfunction is a major complication that precedes death after scorpion envenomation. Here, authors show that heart failure and mortality are caused by excessive acetylcholine release, which requires IL-1R-dependent PGE2 production. Dexamethasone treatment effectively inhibits cardiac dysfunc...

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Main Authors: Mouzarllem B. Reis, Fernanda L. Rodrigues, Natalia Lautherbach, Alexandre Kanashiro, Carlos A. Sorgi, Alyne F. G. Meirelles, Carlos A. A. Silva, Karina F. Zoccal, Camila O. S. Souza, Simone G. Ramos, Alessandra K. Matsuno, Lenaldo B. Rocha, Helio C. Salgado, Luiz C. C. Navegantes, Ísis C. Kettelhut, Palmira Cupo, Luiz G. Gardinassi, Lúcia H. Faccioli
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19232-8
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spelling doaj-3824a55bb5ce42fc8ddfb1f913df0a2a2021-05-11T08:56:07ZengNature Publishing GroupNature Communications2041-17232020-10-0111111210.1038/s41467-020-19232-8Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomationMouzarllem B. Reis0Fernanda L. Rodrigues1Natalia Lautherbach2Alexandre Kanashiro3Carlos A. Sorgi4Alyne F. G. Meirelles5Carlos A. A. Silva6Karina F. Zoccal7Camila O. S. Souza8Simone G. Ramos9Alessandra K. Matsuno10Lenaldo B. Rocha11Helio C. Salgado12Luiz C. C. Navegantes13Ísis C. Kettelhut14Palmira Cupo15Luiz G. Gardinassi16Lúcia H. Faccioli17Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São PauloDepartamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São PauloDepartamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São PauloDepartamento de Neurociências e Ciências do Comportamento, Faculdade de Medicina de Ribeirão Preto, Universidade de São PauloDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São PauloDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São PauloDepartamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São PauloCentro Universitário Barão de MauáDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São PauloDepartamento de Patologia e Medicina Legal, Faculdade de Medicina de Ribeirão PretoDepartamento de Puericultura e Pediatria, Faculdade de Medicina de Ribeirão PretoInstituto de Ciências Biológicas e Naturais, Universidade Federal do Triângulo MineiroDepartamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São PauloDepartamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São PauloDepartamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São PauloDepartamento de Puericultura e Pediatria, Faculdade de Medicina de Ribeirão PretoDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São PauloDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São PauloCardiac dysfunction is a major complication that precedes death after scorpion envenomation. Here, authors show that heart failure and mortality are caused by excessive acetylcholine release, which requires IL-1R-dependent PGE2 production. Dexamethasone treatment effectively inhibits cardiac dysfunction and mortality.https://doi.org/10.1038/s41467-020-19232-8
collection DOAJ
language English
format Article
sources DOAJ
author Mouzarllem B. Reis
Fernanda L. Rodrigues
Natalia Lautherbach
Alexandre Kanashiro
Carlos A. Sorgi
Alyne F. G. Meirelles
Carlos A. A. Silva
Karina F. Zoccal
Camila O. S. Souza
Simone G. Ramos
Alessandra K. Matsuno
Lenaldo B. Rocha
Helio C. Salgado
Luiz C. C. Navegantes
Ísis C. Kettelhut
Palmira Cupo
Luiz G. Gardinassi
Lúcia H. Faccioli
spellingShingle Mouzarllem B. Reis
Fernanda L. Rodrigues
Natalia Lautherbach
Alexandre Kanashiro
Carlos A. Sorgi
Alyne F. G. Meirelles
Carlos A. A. Silva
Karina F. Zoccal
Camila O. S. Souza
Simone G. Ramos
Alessandra K. Matsuno
Lenaldo B. Rocha
Helio C. Salgado
Luiz C. C. Navegantes
Ísis C. Kettelhut
Palmira Cupo
Luiz G. Gardinassi
Lúcia H. Faccioli
Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation
Nature Communications
author_facet Mouzarllem B. Reis
Fernanda L. Rodrigues
Natalia Lautherbach
Alexandre Kanashiro
Carlos A. Sorgi
Alyne F. G. Meirelles
Carlos A. A. Silva
Karina F. Zoccal
Camila O. S. Souza
Simone G. Ramos
Alessandra K. Matsuno
Lenaldo B. Rocha
Helio C. Salgado
Luiz C. C. Navegantes
Ísis C. Kettelhut
Palmira Cupo
Luiz G. Gardinassi
Lúcia H. Faccioli
author_sort Mouzarllem B. Reis
title Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation
title_short Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation
title_full Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation
title_fullStr Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation
title_full_unstemmed Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation
title_sort interleukin-1 receptor-induced pge2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-10-01
description Cardiac dysfunction is a major complication that precedes death after scorpion envenomation. Here, authors show that heart failure and mortality are caused by excessive acetylcholine release, which requires IL-1R-dependent PGE2 production. Dexamethasone treatment effectively inhibits cardiac dysfunction and mortality.
url https://doi.org/10.1038/s41467-020-19232-8
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