Prevalence and correlates of beta human papillomavirus detection in fingernail samples from mid-adult women
Cutaneous human papillomaviruses (HPVs) have not been evaluated in fingernails from healthy individuals. To determine prevalence and correlates of β-HPVs in fingernails from healthy mid-adult women, we tested archived samples collected from 2011 to 2012 using a multiplex PCR combined with Luminex te...
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doaj-382fbb0ca9a2420cbcfa7d7832ebc8a92020-11-24T20:44:11ZengElsevierPapillomavirus Research2405-85212018-06-01515Prevalence and correlates of beta human papillomavirus detection in fingernail samples from mid-adult womenRachel L. Winer0Tarik Gheit1Stephen Cherne2John Lin3Joshua E. Stern4Mario Poljak5Qinghua Feng6Massimo Tommasino7Department of Epidemiology, University of Washington, Seattle, WA, USA; Correspondence to: University of Washington HPV Research Group, Box 359933, 325 9th Ave., Seattle, WA 98104, USA.Infections and Cancer Biology Group, International Agency for Research on Cancer-World Health Organization, Lyon, FranceDepartment of Pathology, University of Washington, Seattle, WA, USADepartment of Pathology, University of Washington, Seattle, WA, USADepartment of Global Health, University of Washington, Seattle, WA, USAInstitute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, SloveniaFIDALAB, Seattle, WA, USAInfections and Cancer Biology Group, International Agency for Research on Cancer-World Health Organization, Lyon, FranceCutaneous human papillomaviruses (HPVs) have not been evaluated in fingernails from healthy individuals. To determine prevalence and correlates of β-HPVs in fingernails from healthy mid-adult women, we tested archived samples collected from 2011 to 2012 using a multiplex PCR combined with Luminex technology for 46 β-HPV genotypes. One hundred thirteen (61.1%) of 185 fingernail samples were positive for β-HPV, and the median number of types detected in positive samples was 2 (interquartile range: 1–4). The most common genotypes detected were HPV-23 (β−2) (13.5%), HPV-38 (β−2) (13.0%), HPV-5 (β−1) (9.2%), HPV-107 (β−2) (8.7%), and HPV-120 (β−2) (8.7%). In multivariate analysis, β-HPV detection was associated with age (prevalence ratio [PR] for women 40–51 years versus 30–39 years = 1.30, 95% CI: 1.05–1.62) and race (PR for non-white versus white race = 0.65, 95% CI: 0.45–0.94). The prevalence of β-HPV in fingernail samples from healthy mid-adult women was similar to the prevalence of β-HPV reported at other cutaneous sites in prior studies. We did not identify any significant health or sexual behavior predictors of β-HPV detection in fingernails. Our results support the hypothesis that fingers may serve as a source of transmission or autoinoculation of cutaneous HPVs to other anatomic sites. Keywords: Fingernails, Women, Beta-HPV, Prevalence, Mid-adult, Risk factorhttp://www.sciencedirect.com/science/article/pii/S2405852117300332 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rachel L. Winer Tarik Gheit Stephen Cherne John Lin Joshua E. Stern Mario Poljak Qinghua Feng Massimo Tommasino |
spellingShingle |
Rachel L. Winer Tarik Gheit Stephen Cherne John Lin Joshua E. Stern Mario Poljak Qinghua Feng Massimo Tommasino Prevalence and correlates of beta human papillomavirus detection in fingernail samples from mid-adult women Papillomavirus Research |
author_facet |
Rachel L. Winer Tarik Gheit Stephen Cherne John Lin Joshua E. Stern Mario Poljak Qinghua Feng Massimo Tommasino |
author_sort |
Rachel L. Winer |
title |
Prevalence and correlates of beta human papillomavirus detection in fingernail samples from mid-adult women |
title_short |
Prevalence and correlates of beta human papillomavirus detection in fingernail samples from mid-adult women |
title_full |
Prevalence and correlates of beta human papillomavirus detection in fingernail samples from mid-adult women |
title_fullStr |
Prevalence and correlates of beta human papillomavirus detection in fingernail samples from mid-adult women |
title_full_unstemmed |
Prevalence and correlates of beta human papillomavirus detection in fingernail samples from mid-adult women |
title_sort |
prevalence and correlates of beta human papillomavirus detection in fingernail samples from mid-adult women |
publisher |
Elsevier |
series |
Papillomavirus Research |
issn |
2405-8521 |
publishDate |
2018-06-01 |
description |
Cutaneous human papillomaviruses (HPVs) have not been evaluated in fingernails from healthy individuals. To determine prevalence and correlates of β-HPVs in fingernails from healthy mid-adult women, we tested archived samples collected from 2011 to 2012 using a multiplex PCR combined with Luminex technology for 46 β-HPV genotypes. One hundred thirteen (61.1%) of 185 fingernail samples were positive for β-HPV, and the median number of types detected in positive samples was 2 (interquartile range: 1–4). The most common genotypes detected were HPV-23 (β−2) (13.5%), HPV-38 (β−2) (13.0%), HPV-5 (β−1) (9.2%), HPV-107 (β−2) (8.7%), and HPV-120 (β−2) (8.7%). In multivariate analysis, β-HPV detection was associated with age (prevalence ratio [PR] for women 40–51 years versus 30–39 years = 1.30, 95% CI: 1.05–1.62) and race (PR for non-white versus white race = 0.65, 95% CI: 0.45–0.94). The prevalence of β-HPV in fingernail samples from healthy mid-adult women was similar to the prevalence of β-HPV reported at other cutaneous sites in prior studies. We did not identify any significant health or sexual behavior predictors of β-HPV detection in fingernails. Our results support the hypothesis that fingers may serve as a source of transmission or autoinoculation of cutaneous HPVs to other anatomic sites. Keywords: Fingernails, Women, Beta-HPV, Prevalence, Mid-adult, Risk factor |
url |
http://www.sciencedirect.com/science/article/pii/S2405852117300332 |
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