Colonization of dermal arterioles by Neisseria meningitidis provides a safe haven from neutrophils

The human pathogen Neisseria meningitidis colonizes blood vessels and causes vascular damage, despite a neutrophil-rich inflammatory infiltrate. Here, Manriquez et al. use a humanized mouse model to show that pathogen colonization of capillaries and arterioles creates an intravascular niche that pre...

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Main Authors:	Valeria Manriquez, Pierre Nivoit, Tomas Urbina, Hebert Echenique-Rivera, Keira Melican, Marie-Paule Fernandez-Gerlinger, Patricia Flamant, Taliah Schmitt, Patrick Bruneval, Dorian Obino, Guillaume Duménil
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-24797-z

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spelling	doaj-3831caa54fa047ecaa07a6a930b570452021-08-01T11:37:56ZengNature Publishing GroupNature Communications2041-17232021-07-0112111510.1038/s41467-021-24797-zColonization of dermal arterioles by Neisseria meningitidis provides a safe haven from neutrophilsValeria Manriquez0Pierre Nivoit1Tomas Urbina2Hebert Echenique-Rivera3Keira Melican4Marie-Paule Fernandez-Gerlinger5Patricia Flamant6Taliah Schmitt7Patrick Bruneval8Dorian Obino9Guillaume Duménil10Pathogenesis of Vascular Infections unit, INSERM, Institut PasteurPathogenesis of Vascular Infections unit, INSERM, Institut PasteurPathogenesis of Vascular Infections unit, INSERM, Institut PasteurPathogenesis of Vascular Infections unit, INSERM, Institut PasteurPathogenesis of Vascular Infections unit, INSERM, Institut PasteurPathogenesis of Vascular Infections unit, INSERM, Institut PasteurExperimental Neuropathology Unit, Institut PasteurParis Saint-Joseph HospitalService d’Anatomie Pathologie, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris (AP-HP)Pathogenesis of Vascular Infections unit, INSERM, Institut PasteurPathogenesis of Vascular Infections unit, INSERM, Institut PasteurThe human pathogen Neisseria meningitidis colonizes blood vessels and causes vascular damage, despite a neutrophil-rich inflammatory infiltrate. Here, Manriquez et al. use a humanized mouse model to show that pathogen colonization of capillaries and arterioles creates an intravascular niche that precludes an effective action of neutrophils.https://doi.org/10.1038/s41467-021-24797-z
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Valeria Manriquez Pierre Nivoit Tomas Urbina Hebert Echenique-Rivera Keira Melican Marie-Paule Fernandez-Gerlinger Patricia Flamant Taliah Schmitt Patrick Bruneval Dorian Obino Guillaume Duménil
spellingShingle	Valeria Manriquez Pierre Nivoit Tomas Urbina Hebert Echenique-Rivera Keira Melican Marie-Paule Fernandez-Gerlinger Patricia Flamant Taliah Schmitt Patrick Bruneval Dorian Obino Guillaume Duménil Colonization of dermal arterioles by Neisseria meningitidis provides a safe haven from neutrophils Nature Communications
author_facet	Valeria Manriquez Pierre Nivoit Tomas Urbina Hebert Echenique-Rivera Keira Melican Marie-Paule Fernandez-Gerlinger Patricia Flamant Taliah Schmitt Patrick Bruneval Dorian Obino Guillaume Duménil
author_sort	Valeria Manriquez
title	Colonization of dermal arterioles by Neisseria meningitidis provides a safe haven from neutrophils
title_short	Colonization of dermal arterioles by Neisseria meningitidis provides a safe haven from neutrophils
title_full	Colonization of dermal arterioles by Neisseria meningitidis provides a safe haven from neutrophils
title_fullStr	Colonization of dermal arterioles by Neisseria meningitidis provides a safe haven from neutrophils
title_full_unstemmed	Colonization of dermal arterioles by Neisseria meningitidis provides a safe haven from neutrophils
title_sort	colonization of dermal arterioles by neisseria meningitidis provides a safe haven from neutrophils
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-07-01
description	The human pathogen Neisseria meningitidis colonizes blood vessels and causes vascular damage, despite a neutrophil-rich inflammatory infiltrate. Here, Manriquez et al. use a humanized mouse model to show that pathogen colonization of capillaries and arterioles creates an intravascular niche that precludes an effective action of neutrophils.
url	https://doi.org/10.1038/s41467-021-24797-z
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Colonization of dermal arterioles by Neisseria meningitidis provides a safe haven from neutrophils

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