Potential Pro-Inflammatory Role Of VEGF In Patients With Crohn’s Disease

Potential Pro-Inflammatory Role Of VEGF In Patients With Crohn’s Disease

The aim of this study was to investigate the expression patterns of p16, p53 and VEGF in affected tissue and serum levels of cytokines TNF-α, IL-6, TGF-β and IL-17 in patients with ulcerative colitis (UC) and fistulating Crohn’s disease (CD). Serum levels of cytokines in patients with ulcerative col...

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Bibliographic Details
Main Authors: Zdravkovic Natasa, Jovanovic Ivan, Radosavljevic Gordana, Zdravkovic Nebojsa, Mitrovic Slobodanka, Arsenijevic Nebojsa
Format: Article
Language:English
Published: Sciendo 2015-12-01
Series:Serbian Journal of Experimental and Clinical Research
Subjects:
ulcerative colitis
Crohn’s disease
p16
p53
VEGF
cytokines
ulcerozni kolitis
Kronova bolest
citokini
Online Access:http://www.degruyter.com/view/j/sjecr.2015.16.issue-4/sjecr-2015-0046/sjecr-2015-0046.xml?format=INT
Description
Summary:The aim of this study was to investigate the expression patterns of p16, p53 and VEGF in affected tissue and serum levels of cytokines TNF-α, IL-6, TGF-β and IL-17 in patients with ulcerative colitis (UC) and fistulating Crohn’s disease (CD). Serum levels of cytokines in patients with ulcerative colitis (n=24) and with Crohn’s disease (n=7) were analysed by ELISA. In colonoscopically obtained biopsies, p16, p53 and vascular endothelial growth factor expression were evaluated by immunohistochemistry.
ISSN:1820-8665
2335-075X

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