Immune Regulatory Activity of Vitamin D3 in Head and Neck Cancer
While vitamin D exhibits a multitude of cellular effects that can impact on cancer development and progression, this review focuses on its immune modulatory effects. These immune modulatory effects can be both direct and indirect. Compared to other cancer types, head and neck squamous cell carcinoma...
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| Format: | Article |
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MDPI AG
2013-08-01
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| Series: | Cancers |
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| Online Access: | http://www.mdpi.com/2072-6694/5/3/1072 |
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doaj-3838830b685f4b66a99638487b5a7ed82020-11-24T20:55:18ZengMDPI AGCancers2072-66942013-08-01531072108510.3390/cancers5031072Immune Regulatory Activity of Vitamin D3 in Head and Neck CancerM. Rita I. YoungTerry A. DayWhile vitamin D exhibits a multitude of cellular effects that can impact on cancer development and progression, this review focuses on its immune modulatory effects. These immune modulatory effects can be both direct and indirect. Compared to other cancer types, head and neck squamous cell carcinomas (HNSCC) have received less attention, but are a fascination immunologically because of the profound extent to which they inhibit immune defenses. This review describes the mechanisms of some of these immune inhibitory processes and how vitamin D can help overcome aspects of this immune suppression.http://www.mdpi.com/2072-6694/5/3/1072head and neck cancerHNSCCimmune modulationimmune suppressionsuppressor cellsvitamin D |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
M. Rita I. Young Terry A. Day |
| spellingShingle |
M. Rita I. Young Terry A. Day Immune Regulatory Activity of Vitamin D3 in Head and Neck Cancer Cancers head and neck cancer HNSCC immune modulation immune suppression suppressor cells vitamin D |
| author_facet |
M. Rita I. Young Terry A. Day |
| author_sort |
M. Rita I. Young |
| title |
Immune Regulatory Activity of Vitamin D3 in Head and Neck Cancer |
| title_short |
Immune Regulatory Activity of Vitamin D3 in Head and Neck Cancer |
| title_full |
Immune Regulatory Activity of Vitamin D3 in Head and Neck Cancer |
| title_fullStr |
Immune Regulatory Activity of Vitamin D3 in Head and Neck Cancer |
| title_full_unstemmed |
Immune Regulatory Activity of Vitamin D3 in Head and Neck Cancer |
| title_sort |
immune regulatory activity of vitamin d3 in head and neck cancer |
| publisher |
MDPI AG |
| series |
Cancers |
| issn |
2072-6694 |
| publishDate |
2013-08-01 |
| description |
While vitamin D exhibits a multitude of cellular effects that can impact on cancer development and progression, this review focuses on its immune modulatory effects. These immune modulatory effects can be both direct and indirect. Compared to other cancer types, head and neck squamous cell carcinomas (HNSCC) have received less attention, but are a fascination immunologically because of the profound extent to which they inhibit immune defenses. This review describes the mechanisms of some of these immune inhibitory processes and how vitamin D can help overcome aspects of this immune suppression. |
| topic |
head and neck cancer HNSCC immune modulation immune suppression suppressor cells vitamin D |
| url |
http://www.mdpi.com/2072-6694/5/3/1072 |
| work_keys_str_mv |
AT mritaiyoung immuneregulatoryactivityofvitamind3inheadandneckcancer AT terryaday immuneregulatoryactivityofvitamind3inheadandneckcancer |
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1716791873688829952 |