Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells
Epithelial tissue mononuclear phagocytes (MNP) can transmit HIV to CD4 T cells, but less is known about sub-epithelial cells. Here, the authors describe MNPs in human anogenital and colorectal tissues and find that CD14+CD1c+ monocyte-derived dendritic cells and langerin-expressing conventional dend...
Main Authors: | Jake W. Rhodes, Rachel A. Botting, Kirstie M. Bertram, Erica E. Vine, Hafsa Rana, Heeva Baharlou, Peter Vegh, Thomas R. O’Neil, Anneliese S. Ashhurst, James Fletcher, Grant P. Parnell, J. Dinny Graham, Najla Nasr, Jake J. K. Lim, Laith Barnouti, Peter Haertsch, Martijn P. Gosselink, Angelina Di Re, Faizur Reza, Grahame Ctercteko, Gregory J. Jenkins, Andrew J. Brooks, Ellis Patrick, Scott N. Byrne, Eric Hunter, Muzlifah A. Haniffa, Anthony L. Cunningham, Andrew N. Harman |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-04-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-021-22375-x |
Similar Items
-
Identification of HIV transmitting CD11c+ human epidermal dendritic cells
by: Kirstie M. Bertram, et al.
Published: (2019-06-01) -
Optimal Isolation Protocols for Examining and Interrogating Mononuclear Phagocytes From Human Intestinal Tissue
by: Chloe M. Doyle, et al.
Published: (2021-09-01) -
Prenatal Development and Function of Human Mononuclear Phagocytes
by: Mohi Miah, et al.
Published: (2021-04-01) -
Disseminated anogenital Herpes Simplex With Encephalitis
by: Kaur Sukhjot, et al.
Published: (2001-01-01) -
Targeting of the C-Type Lectin Receptor Langerin Using Bifunctional Mannosylated Antigens
by: Rui-Jun Eveline Li, et al.
Published: (2020-07-01)