Risk factors of CMV replication after allogeneic hematopoietic stem cell transplantation in children and adolescents
Risk factors of CMV replication in early period after allo-HSCT (D0‑D100) were – myeloablative conditioning – HR 3.74 (1.67–8.37), р = 0.001; unrelated donor – HR 2.18 (0.86–5.26), р = 0.10; HLA-matched donor – HR 0.24 (0.05–1.06), р = 0,06. In late posttransplant period (from D+100) significant ris...
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doaj-3841984d2cd742d4808711bef857b5d72021-07-29T09:03:04ZrusABV-pressOnkogematologiâ1818-83462014-09-0192455210.17650/1818-8346-2014-9-2-45-52129Risk factors of CMV replication after allogeneic hematopoietic stem cell transplantation in children and adolescentsS. N. Shiriaev0N. V. Stancheva1Ye. V. Morozova2I. M. Barkhatov3M. Yu. Averianova4S. V. Razumova5O. V. Goloshchapov6A. B. Chukhlovin7L. S. Zubarovskaya8B. V. Afanasiev9Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaRaisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaRaisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaRaisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaRaisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaRaisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaRaisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaRaisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaRaisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaRaisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaRisk factors of CMV replication in early period after allo-HSCT (D0‑D100) were – myeloablative conditioning – HR 3.74 (1.67–8.37), р = 0.001; unrelated donor – HR 2.18 (0.86–5.26), р = 0.10; HLA-matched donor – HR 0.24 (0.05–1.06), р = 0,06. In late posttransplant period (from D+100) significant risk factors of CMV-reactivation were (according to multivariate analysis) myeloablative conditioning – HR 13.17 (3.00–57.86), р = 0.001; combination of pretransplant remission of leukemia and using cyclosporine and methotrexate – HR 0.13 (0.03–0.50), р = 0.003; combination of aGVHD and CMV reactivation in early posttransplant period – HR 2.71 (0.86–8.50), р = 0.088; using of bone marrow – HR 0.37 (0.12–1.19), р = 0.095. We revealed the significant association of aGVHD and CMV-reactivation –OR 2.91 (1.07–7.92), р=0.006, and increased rate of cGVHD in patients with CMV replication at third month after allo-HSCT OR – 2.29 (1.03–5.08), р = 0.066. We revealed a tend to decreasing relapse risk in patients who had CMV-replication – HR 0.07 (0.004–1.17), р = 0.06. Cumulative incidence of CMV-disease was 28 %. CMV-disease was lethal in 44 % patients.https://oncohematology.abvpress.ru/ongm/article/view/114acute lymphoblastic leukemiaacute myeloblastic leukemiacytomegalovirusallogeneic hematopoietic stem cell transplantation |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
S. N. Shiriaev N. V. Stancheva Ye. V. Morozova I. M. Barkhatov M. Yu. Averianova S. V. Razumova O. V. Goloshchapov A. B. Chukhlovin L. S. Zubarovskaya B. V. Afanasiev |
spellingShingle |
S. N. Shiriaev N. V. Stancheva Ye. V. Morozova I. M. Barkhatov M. Yu. Averianova S. V. Razumova O. V. Goloshchapov A. B. Chukhlovin L. S. Zubarovskaya B. V. Afanasiev Risk factors of CMV replication after allogeneic hematopoietic stem cell transplantation in children and adolescents Onkogematologiâ acute lymphoblastic leukemia acute myeloblastic leukemia cytomegalovirus allogeneic hematopoietic stem cell transplantation |
author_facet |
S. N. Shiriaev N. V. Stancheva Ye. V. Morozova I. M. Barkhatov M. Yu. Averianova S. V. Razumova O. V. Goloshchapov A. B. Chukhlovin L. S. Zubarovskaya B. V. Afanasiev |
author_sort |
S. N. Shiriaev |
title |
Risk factors of CMV replication after allogeneic hematopoietic stem cell transplantation in children and adolescents |
title_short |
Risk factors of CMV replication after allogeneic hematopoietic stem cell transplantation in children and adolescents |
title_full |
Risk factors of CMV replication after allogeneic hematopoietic stem cell transplantation in children and adolescents |
title_fullStr |
Risk factors of CMV replication after allogeneic hematopoietic stem cell transplantation in children and adolescents |
title_full_unstemmed |
Risk factors of CMV replication after allogeneic hematopoietic stem cell transplantation in children and adolescents |
title_sort |
risk factors of cmv replication after allogeneic hematopoietic stem cell transplantation in children and adolescents |
publisher |
ABV-press |
series |
Onkogematologiâ |
issn |
1818-8346 |
publishDate |
2014-09-01 |
description |
Risk factors of CMV replication in early period after allo-HSCT (D0‑D100) were – myeloablative conditioning – HR 3.74 (1.67–8.37), р = 0.001; unrelated donor – HR 2.18 (0.86–5.26), р = 0.10; HLA-matched donor – HR 0.24 (0.05–1.06), р = 0,06. In late posttransplant period (from D+100) significant risk factors of CMV-reactivation were (according to multivariate analysis) myeloablative conditioning – HR 13.17 (3.00–57.86), р = 0.001; combination of pretransplant remission of leukemia and using cyclosporine and methotrexate – HR 0.13 (0.03–0.50), р = 0.003; combination of aGVHD and CMV reactivation in early posttransplant period – HR 2.71 (0.86–8.50), р = 0.088; using of bone marrow – HR 0.37 (0.12–1.19), р = 0.095. We revealed the significant association of aGVHD and CMV-reactivation –OR 2.91 (1.07–7.92), р=0.006, and increased rate of cGVHD in patients with CMV replication at third month after allo-HSCT OR – 2.29 (1.03–5.08), р = 0.066. We revealed a tend to decreasing relapse risk in patients who had CMV-replication – HR 0.07 (0.004–1.17), р = 0.06. Cumulative incidence of CMV-disease was 28 %. CMV-disease was lethal in 44 % patients. |
topic |
acute lymphoblastic leukemia acute myeloblastic leukemia cytomegalovirus allogeneic hematopoietic stem cell transplantation |
url |
https://oncohematology.abvpress.ru/ongm/article/view/114 |
work_keys_str_mv |
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