Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies.
The CD4 binding site (CD4bs) of the HIV-1 envelope glycoprotein is susceptible to multiple lineages of broadly neutralizing antibodies (bnAbs) that are attractive to elicit with vaccines. The CH235 lineage (VH1-46) of CD4bs bnAbs is particularly attractive because the most mature members neutralize...
Main Authors: | Celia C LaBranche, Rory Henderson, Allen Hsu, Shay Behrens, Xuejun Chen, Tongqing Zhou, Kevin Wiehe, Kevin O Saunders, S Munir Alam, Mattia Bonsignori, Mario J Borgnia, Quentin J Sattentau, Amanda Eaton, Kelli Greene, Hongmei Gao, Hua-Xin Liao, Wilton B Williams, James Peacock, Haili Tang, Lautaro G Perez, Robert J Edwards, Thomas B Kepler, Bette T Korber, Peter D Kwong, John R Mascola, Priyamvada Acharya, Barton F Haynes, David C Montefiori |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2019-09-01
|
Series: | PLoS Pathogens |
Online Access: | https://doi.org/10.1371/journal.ppat.1008026 |
Similar Items
-
Correction: Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies.
by: Celia C LaBranche, et al.
Published: (2019-12-01) -
Envelope deglycosylation enhances antigenicity of HIV-1 gp41 epitopes for both broad neutralizing antibodies and their unmutated ancestor antibodies.
by: Ben-Jiang Ma, et al.
Published: (2011-09-01) -
Priming with DNA encoding functional trimers and boosting with soluble trimeric protein elicited tier 2 neutralizing antibodies in non-human primates
by: Chakrabarti BK, et al.
Published: (2012-09-01) -
Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages
by: Kizzmekia S. Corbett, et al.
Published: (2019-02-01) -
Correction: HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies.
by: Celia C LaBranche, et al.
Published: (2019-03-01)