Decoding odor quality and intensity in the Drosophila brain
To internally reflect the sensory environment, animals create neural maps encoding the external stimulus space. From that primary neural code relevant information has to be extracted for accurate navigation. We analyzed how different odor features such as hedonic valence and intensity are functional...
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doaj-384c730c5ea3487bb972ed73ebc341852021-05-04T23:35:05ZengeLife Sciences Publications LtdeLife2050-084X2014-12-01310.7554/eLife.04147Decoding odor quality and intensity in the Drosophila brainAntonia Strutz0Jan Soelter1Amelie Baschwitz2https://orcid.org/0000-0003-0614-1667Abu Farhan3Veit Grabe4Jürgen Rybak5Markus Knaden6Michael Schmuker7https://orcid.org/0000-0001-6753-4929Bill S Hansson8Silke Sachse9Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Jena, GermanyDepartment for Biology, Pharmacy and Chemistry, Free University Berlin, Neuroinformatics and Theoretical Neuroscience, Berlin, GermanyDepartment of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Jena, GermanyDepartment of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Jena, GermanyDepartment of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Jena, GermanyDepartment of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Jena, GermanyDepartment of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Jena, GermanyDepartment for Biology, Pharmacy and Chemistry, Free University Berlin, Neuroinformatics and Theoretical Neuroscience, Berlin, GermanyDepartment of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Jena, GermanyDepartment of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Jena, GermanyTo internally reflect the sensory environment, animals create neural maps encoding the external stimulus space. From that primary neural code relevant information has to be extracted for accurate navigation. We analyzed how different odor features such as hedonic valence and intensity are functionally integrated in the lateral horn (LH) of the vinegar fly, Drosophila melanogaster. We characterized an olfactory-processing pathway, comprised of inhibitory projection neurons (iPNs) that target the LH exclusively, at morphological, functional and behavioral levels. We demonstrate that iPNs are subdivided into two morphological groups encoding positive hedonic valence or intensity information and conveying these features into separate domains in the LH. Silencing iPNs severely diminished flies' attraction behavior. Moreover, functional imaging disclosed a LH region tuned to repulsive odors comprised exclusively of third-order neurons. We provide evidence for a feature-based map in the LH, and elucidate its role as the center for integrating behaviorally relevant olfactory information.https://elifesciences.org/articles/04147olfactionneural circuitlateral hornantennal lobeodor processingfunctional imaging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Antonia Strutz Jan Soelter Amelie Baschwitz Abu Farhan Veit Grabe Jürgen Rybak Markus Knaden Michael Schmuker Bill S Hansson Silke Sachse |
spellingShingle |
Antonia Strutz Jan Soelter Amelie Baschwitz Abu Farhan Veit Grabe Jürgen Rybak Markus Knaden Michael Schmuker Bill S Hansson Silke Sachse Decoding odor quality and intensity in the Drosophila brain eLife olfaction neural circuit lateral horn antennal lobe odor processing functional imaging |
author_facet |
Antonia Strutz Jan Soelter Amelie Baschwitz Abu Farhan Veit Grabe Jürgen Rybak Markus Knaden Michael Schmuker Bill S Hansson Silke Sachse |
author_sort |
Antonia Strutz |
title |
Decoding odor quality and intensity in the Drosophila brain |
title_short |
Decoding odor quality and intensity in the Drosophila brain |
title_full |
Decoding odor quality and intensity in the Drosophila brain |
title_fullStr |
Decoding odor quality and intensity in the Drosophila brain |
title_full_unstemmed |
Decoding odor quality and intensity in the Drosophila brain |
title_sort |
decoding odor quality and intensity in the drosophila brain |
publisher |
eLife Sciences Publications Ltd |
series |
eLife |
issn |
2050-084X |
publishDate |
2014-12-01 |
description |
To internally reflect the sensory environment, animals create neural maps encoding the external stimulus space. From that primary neural code relevant information has to be extracted for accurate navigation. We analyzed how different odor features such as hedonic valence and intensity are functionally integrated in the lateral horn (LH) of the vinegar fly, Drosophila melanogaster. We characterized an olfactory-processing pathway, comprised of inhibitory projection neurons (iPNs) that target the LH exclusively, at morphological, functional and behavioral levels. We demonstrate that iPNs are subdivided into two morphological groups encoding positive hedonic valence or intensity information and conveying these features into separate domains in the LH. Silencing iPNs severely diminished flies' attraction behavior. Moreover, functional imaging disclosed a LH region tuned to repulsive odors comprised exclusively of third-order neurons. We provide evidence for a feature-based map in the LH, and elucidate its role as the center for integrating behaviorally relevant olfactory information. |
topic |
olfaction neural circuit lateral horn antennal lobe odor processing functional imaging |
url |
https://elifesciences.org/articles/04147 |
work_keys_str_mv |
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