Nifedipine effects on blood cells and rheology in arterial hypertension and pregnancy

• Main Authors: N. K. Runikhina, O. N. Tkacheva, B. Ya. Bart
• Format: Article
• Language: Russian
• Published: «SILICEA-POLIGRAF» LLC 2007-12-01
• Series: Кардиоваскулярная терапия и профилактика
• Subjects: pregnant women; blood rheology; arterial hypertension; platelet and red blood cell properties in pregnancy; nifedipine
• Online Access: https://cardiovascular.elpub.ru/jour/article/view/1416

Arterial hypertension (AH) in pregnancy is associated with systemic endothelial damage, vasoconstriction, and blood rheology disturbances, that results in microcirculation disorders, tissue and organ ischemia. Antihypertensive therapy effects on endothelium and blood cells in hypertensive pregnant women should be taken into account. Recent experimental and clinical studies show that nifedipine has good antihypertensive effect in pregnancy, is safe, and beneficial for endothelium, platelets and red blood cells. Nifedipine non-hemodynamic effects support its use as a first-line medication in pregnancy-associated hypertensive states.