Relationship of the Pro12Ala Polymorphism on the PPARy2 Gene With the Body Composition of Practitioners of Cyclic Exercises
This study aimed to verify the association between the genotypic of the receptor gene activated by peroxisome proliferators gamma 2 (PPARy2) and the body composition and the specific indicators of adiposity in practitioners physical exercises, considering nutritional intake, age, and training load a...
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2021-01-01
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Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2020.633721/full |
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language |
English |
format |
Article |
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DOAJ |
author |
Raquel Suelen Brito da Silva Raquel Suelen Brito da Silva Darlene Camati Persuhn Francisca Karinny Lemos Barbosa Francisca Karinny Lemos Barbosa Marizângela Ferreira de Souza Klécia de Farias Sena Klécia de Farias Sena Matheus da Silveira Costa Matheus da Silveira Costa Gisele Augusta Maciel Franca Caroline Severo de Assis Glêbia Alexa Cardoso Glêbia Alexa Cardoso Alexandre Sérgio Silva Alexandre Sérgio Silva |
spellingShingle |
Raquel Suelen Brito da Silva Raquel Suelen Brito da Silva Darlene Camati Persuhn Francisca Karinny Lemos Barbosa Francisca Karinny Lemos Barbosa Marizângela Ferreira de Souza Klécia de Farias Sena Klécia de Farias Sena Matheus da Silveira Costa Matheus da Silveira Costa Gisele Augusta Maciel Franca Caroline Severo de Assis Glêbia Alexa Cardoso Glêbia Alexa Cardoso Alexandre Sérgio Silva Alexandre Sérgio Silva Relationship of the Pro12Ala Polymorphism on the PPARy2 Gene With the Body Composition of Practitioners of Cyclic Exercises Frontiers in Physiology body composition genetic polymorphism PPARy2 energy expenditure exercise |
author_facet |
Raquel Suelen Brito da Silva Raquel Suelen Brito da Silva Darlene Camati Persuhn Francisca Karinny Lemos Barbosa Francisca Karinny Lemos Barbosa Marizângela Ferreira de Souza Klécia de Farias Sena Klécia de Farias Sena Matheus da Silveira Costa Matheus da Silveira Costa Gisele Augusta Maciel Franca Caroline Severo de Assis Glêbia Alexa Cardoso Glêbia Alexa Cardoso Alexandre Sérgio Silva Alexandre Sérgio Silva |
author_sort |
Raquel Suelen Brito da Silva |
title |
Relationship of the Pro12Ala Polymorphism on the PPARy2 Gene With the Body Composition of Practitioners of Cyclic Exercises |
title_short |
Relationship of the Pro12Ala Polymorphism on the PPARy2 Gene With the Body Composition of Practitioners of Cyclic Exercises |
title_full |
Relationship of the Pro12Ala Polymorphism on the PPARy2 Gene With the Body Composition of Practitioners of Cyclic Exercises |
title_fullStr |
Relationship of the Pro12Ala Polymorphism on the PPARy2 Gene With the Body Composition of Practitioners of Cyclic Exercises |
title_full_unstemmed |
Relationship of the Pro12Ala Polymorphism on the PPARy2 Gene With the Body Composition of Practitioners of Cyclic Exercises |
title_sort |
relationship of the pro12ala polymorphism on the ppary2 gene with the body composition of practitioners of cyclic exercises |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2021-01-01 |
description |
This study aimed to verify the association between the genotypic of the receptor gene activated by peroxisome proliferators gamma 2 (PPARy2) and the body composition and the specific indicators of adiposity in practitioners physical exercises, considering nutritional intake, age, and training load as influencing factors. It was conducted a cross-sectional study with 335 adults (47.9 ± 12.7 years, 138 men, body mass index/BMI = 27.0 ± 4.9 kg/m2), practitioners of aerobic exercises in cyclical modalities (running, walking and/or cycling, who spent 328.3 ± 193.6 kcal/day on physical training). The genotyping of the Pro12Ala polymorphism was performed using the PCR-RFLP technique and the body composition measured by bioimpedance (InBody 720). Energy expenditure was based on the compendium of physical activities and caloric intake was measured by 24 h recall questionnaire. The higher prevalence was for the Pro/Pro genotype (76.1% vs. 23.9% of Pro/Ala). Pro/Pro genotypic group showed significant higher mean values for body mass (BM) (p < 0.03 for men and p < 0.02 for women) and BMI (p < 0.00 for men and p < 0.02 for women) and %FAT (p < 0.00), waist-hip ratio (WHR) (p < 0.04), and visceral fat (VF) (p < 0.00) only in men compared to Pro/Ala. Higher frequency of Pro/Pro was observed in the category indicating BMI (p < 0.00 for men and p < 0.03 for women), WRH (p < 0.03 for men and p < 0.00 for women), and %FAT (p < 0.03) (in the latter case, only among men. It was also observed that the frequency of distribution of Pro/Ala in the eutrophic category of the BMI remained independent of all influencers, while WHR and %FAT were independent of the training load, but influenced by nutritional intake and age. In women, the frequency of Pro/Ala distribution at the lowest BMI and WHR values remained independent of all confounding variables. It is concluded that the Pro12Ala polymorphism in the PPARy2 gene consistently influences indicators of body composition and adiposity, regardless of the practitioners of physical training, but the relationship needs to be considered according to age and nutritional intake. |
topic |
body composition genetic polymorphism PPARy2 energy expenditure exercise |
url |
https://www.frontiersin.org/articles/10.3389/fphys.2020.633721/full |
work_keys_str_mv |
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doaj-3864c9a502de40cd96df7f5322a7646f2021-01-12T06:10:08ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-01-011110.3389/fphys.2020.633721633721Relationship of the Pro12Ala Polymorphism on the PPARy2 Gene With the Body Composition of Practitioners of Cyclic ExercisesRaquel Suelen Brito da Silva0Raquel Suelen Brito da Silva1Darlene Camati Persuhn2Francisca Karinny Lemos Barbosa3Francisca Karinny Lemos Barbosa4Marizângela Ferreira de Souza5Klécia de Farias Sena6Klécia de Farias Sena7Matheus da Silveira Costa8Matheus da Silveira Costa9Gisele Augusta Maciel Franca10Caroline Severo de Assis11Glêbia Alexa Cardoso12Glêbia Alexa Cardoso13Alexandre Sérgio Silva14Alexandre Sérgio Silva15Laboratory of Applied Studies in Physical Training to Performance and Health-LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, BrazilAssociate Postgraduate Program in Physical Education – UPE/UFPB, Department of Physical Education, Federal University of Paraíba, João Pessoa, BrazilPost Graduate Program in Nutrition Sciences, Federal University of Paraíba (PPGCN/UFPB), João Pessoa, BrazilLaboratory of Applied Studies in Physical Training to Performance and Health-LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, BrazilPost Graduate Program in Nutrition Sciences, Federal University of Paraíba (PPGCN/UFPB), João Pessoa, BrazilLaboratory of Applied Studies in Physical Training to Performance and Health-LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, BrazilLaboratory of Applied Studies in Physical Training to Performance and Health-LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, BrazilAssociate Postgraduate Program in Physical Education – UPE/UFPB, Department of Physical Education, Federal University of Paraíba, João Pessoa, BrazilLaboratory of Applied Studies in Physical Training to Performance and Health-LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, BrazilPost Graduate Program in Nutrition Sciences, Federal University of Paraíba (PPGCN/UFPB), João Pessoa, BrazilDe Leve Clinic, João Pessoa, BrazilPost Graduate Program in Nutrition Sciences, Federal University of Paraíba (PPGCN/UFPB), João Pessoa, BrazilLaboratory of Applied Studies in Physical Training to Performance and Health-LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, BrazilAssociate Postgraduate Program in Physical Education – UPE/UFPB, Department of Physical Education, Federal University of Paraíba, João Pessoa, BrazilLaboratory of Applied Studies in Physical Training to Performance and Health-LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, BrazilAssociate Postgraduate Program in Physical Education – UPE/UFPB, Department of Physical Education, Federal University of Paraíba, João Pessoa, BrazilThis study aimed to verify the association between the genotypic of the receptor gene activated by peroxisome proliferators gamma 2 (PPARy2) and the body composition and the specific indicators of adiposity in practitioners physical exercises, considering nutritional intake, age, and training load as influencing factors. It was conducted a cross-sectional study with 335 adults (47.9 ± 12.7 years, 138 men, body mass index/BMI = 27.0 ± 4.9 kg/m2), practitioners of aerobic exercises in cyclical modalities (running, walking and/or cycling, who spent 328.3 ± 193.6 kcal/day on physical training). The genotyping of the Pro12Ala polymorphism was performed using the PCR-RFLP technique and the body composition measured by bioimpedance (InBody 720). Energy expenditure was based on the compendium of physical activities and caloric intake was measured by 24 h recall questionnaire. The higher prevalence was for the Pro/Pro genotype (76.1% vs. 23.9% of Pro/Ala). Pro/Pro genotypic group showed significant higher mean values for body mass (BM) (p < 0.03 for men and p < 0.02 for women) and BMI (p < 0.00 for men and p < 0.02 for women) and %FAT (p < 0.00), waist-hip ratio (WHR) (p < 0.04), and visceral fat (VF) (p < 0.00) only in men compared to Pro/Ala. Higher frequency of Pro/Pro was observed in the category indicating BMI (p < 0.00 for men and p < 0.03 for women), WRH (p < 0.03 for men and p < 0.00 for women), and %FAT (p < 0.03) (in the latter case, only among men. It was also observed that the frequency of distribution of Pro/Ala in the eutrophic category of the BMI remained independent of all influencers, while WHR and %FAT were independent of the training load, but influenced by nutritional intake and age. In women, the frequency of Pro/Ala distribution at the lowest BMI and WHR values remained independent of all confounding variables. It is concluded that the Pro12Ala polymorphism in the PPARy2 gene consistently influences indicators of body composition and adiposity, regardless of the practitioners of physical training, but the relationship needs to be considered according to age and nutritional intake.https://www.frontiersin.org/articles/10.3389/fphys.2020.633721/fullbody compositiongenetic polymorphismPPARy2energy expenditureexercise |