Relationship of the Pro12Ala Polymorphism on the PPARy2 Gene With the Body Composition of Practitioners of Cyclic Exercises

This study aimed to verify the association between the genotypic of the receptor gene activated by peroxisome proliferators gamma 2 (PPARy2) and the body composition and the specific indicators of adiposity in practitioners physical exercises, considering nutritional intake, age, and training load a...

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Main Authors: Raquel Suelen Brito da Silva, Darlene Camati Persuhn, Francisca Karinny Lemos Barbosa, Marizângela Ferreira de Souza, Klécia de Farias Sena, Matheus da Silveira Costa, Gisele Augusta Maciel Franca, Caroline Severo de Assis, Glêbia Alexa Cardoso, Alexandre Sérgio Silva
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Physiology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.633721/full
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author Raquel Suelen Brito da Silva
Raquel Suelen Brito da Silva
Darlene Camati Persuhn
Francisca Karinny Lemos Barbosa
Francisca Karinny Lemos Barbosa
Marizângela Ferreira de Souza
Klécia de Farias Sena
Klécia de Farias Sena
Matheus da Silveira Costa
Matheus da Silveira Costa
Gisele Augusta Maciel Franca
Caroline Severo de Assis
Glêbia Alexa Cardoso
Glêbia Alexa Cardoso
Alexandre Sérgio Silva
Alexandre Sérgio Silva
spellingShingle Raquel Suelen Brito da Silva
Raquel Suelen Brito da Silva
Darlene Camati Persuhn
Francisca Karinny Lemos Barbosa
Francisca Karinny Lemos Barbosa
Marizângela Ferreira de Souza
Klécia de Farias Sena
Klécia de Farias Sena
Matheus da Silveira Costa
Matheus da Silveira Costa
Gisele Augusta Maciel Franca
Caroline Severo de Assis
Glêbia Alexa Cardoso
Glêbia Alexa Cardoso
Alexandre Sérgio Silva
Alexandre Sérgio Silva
Relationship of the Pro12Ala Polymorphism on the PPARy2 Gene With the Body Composition of Practitioners of Cyclic Exercises
Frontiers in Physiology
body composition
genetic polymorphism
PPARy2
energy expenditure
exercise
author_facet Raquel Suelen Brito da Silva
Raquel Suelen Brito da Silva
Darlene Camati Persuhn
Francisca Karinny Lemos Barbosa
Francisca Karinny Lemos Barbosa
Marizângela Ferreira de Souza
Klécia de Farias Sena
Klécia de Farias Sena
Matheus da Silveira Costa
Matheus da Silveira Costa
Gisele Augusta Maciel Franca
Caroline Severo de Assis
Glêbia Alexa Cardoso
Glêbia Alexa Cardoso
Alexandre Sérgio Silva
Alexandre Sérgio Silva
author_sort Raquel Suelen Brito da Silva
title Relationship of the Pro12Ala Polymorphism on the PPARy2 Gene With the Body Composition of Practitioners of Cyclic Exercises
title_short Relationship of the Pro12Ala Polymorphism on the PPARy2 Gene With the Body Composition of Practitioners of Cyclic Exercises
title_full Relationship of the Pro12Ala Polymorphism on the PPARy2 Gene With the Body Composition of Practitioners of Cyclic Exercises
title_fullStr Relationship of the Pro12Ala Polymorphism on the PPARy2 Gene With the Body Composition of Practitioners of Cyclic Exercises
title_full_unstemmed Relationship of the Pro12Ala Polymorphism on the PPARy2 Gene With the Body Composition of Practitioners of Cyclic Exercises
title_sort relationship of the pro12ala polymorphism on the ppary2 gene with the body composition of practitioners of cyclic exercises
publisher Frontiers Media S.A.
series Frontiers in Physiology
issn 1664-042X
publishDate 2021-01-01
description This study aimed to verify the association between the genotypic of the receptor gene activated by peroxisome proliferators gamma 2 (PPARy2) and the body composition and the specific indicators of adiposity in practitioners physical exercises, considering nutritional intake, age, and training load as influencing factors. It was conducted a cross-sectional study with 335 adults (47.9 ± 12.7 years, 138 men, body mass index/BMI = 27.0 ± 4.9 kg/m2), practitioners of aerobic exercises in cyclical modalities (running, walking and/or cycling, who spent 328.3 ± 193.6 kcal/day on physical training). The genotyping of the Pro12Ala polymorphism was performed using the PCR-RFLP technique and the body composition measured by bioimpedance (InBody 720). Energy expenditure was based on the compendium of physical activities and caloric intake was measured by 24 h recall questionnaire. The higher prevalence was for the Pro/Pro genotype (76.1% vs. 23.9% of Pro/Ala). Pro/Pro genotypic group showed significant higher mean values for body mass (BM) (p < 0.03 for men and p < 0.02 for women) and BMI (p < 0.00 for men and p < 0.02 for women) and %FAT (p < 0.00), waist-hip ratio (WHR) (p < 0.04), and visceral fat (VF) (p < 0.00) only in men compared to Pro/Ala. Higher frequency of Pro/Pro was observed in the category indicating BMI (p < 0.00 for men and p < 0.03 for women), WRH (p < 0.03 for men and p < 0.00 for women), and %FAT (p < 0.03) (in the latter case, only among men. It was also observed that the frequency of distribution of Pro/Ala in the eutrophic category of the BMI remained independent of all influencers, while WHR and %FAT were independent of the training load, but influenced by nutritional intake and age. In women, the frequency of Pro/Ala distribution at the lowest BMI and WHR values remained independent of all confounding variables. It is concluded that the Pro12Ala polymorphism in the PPARy2 gene consistently influences indicators of body composition and adiposity, regardless of the practitioners of physical training, but the relationship needs to be considered according to age and nutritional intake.
topic body composition
genetic polymorphism
PPARy2
energy expenditure
exercise
url https://www.frontiersin.org/articles/10.3389/fphys.2020.633721/full
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spelling doaj-3864c9a502de40cd96df7f5322a7646f2021-01-12T06:10:08ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-01-011110.3389/fphys.2020.633721633721Relationship of the Pro12Ala Polymorphism on the PPARy2 Gene With the Body Composition of Practitioners of Cyclic ExercisesRaquel Suelen Brito da Silva0Raquel Suelen Brito da Silva1Darlene Camati Persuhn2Francisca Karinny Lemos Barbosa3Francisca Karinny Lemos Barbosa4Marizângela Ferreira de Souza5Klécia de Farias Sena6Klécia de Farias Sena7Matheus da Silveira Costa8Matheus da Silveira Costa9Gisele Augusta Maciel Franca10Caroline Severo de Assis11Glêbia Alexa Cardoso12Glêbia Alexa Cardoso13Alexandre Sérgio Silva14Alexandre Sérgio Silva15Laboratory of Applied Studies in Physical Training to Performance and Health-LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, BrazilAssociate Postgraduate Program in Physical Education – UPE/UFPB, Department of Physical Education, Federal University of Paraíba, João Pessoa, BrazilPost Graduate Program in Nutrition Sciences, Federal University of Paraíba (PPGCN/UFPB), João Pessoa, BrazilLaboratory of Applied Studies in Physical Training to Performance and Health-LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, BrazilPost Graduate Program in Nutrition Sciences, Federal University of Paraíba (PPGCN/UFPB), João Pessoa, BrazilLaboratory of Applied Studies in Physical Training to Performance and Health-LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, BrazilLaboratory of Applied Studies in Physical Training to Performance and Health-LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, BrazilAssociate Postgraduate Program in Physical Education – UPE/UFPB, Department of Physical Education, Federal University of Paraíba, João Pessoa, BrazilLaboratory of Applied Studies in Physical Training to Performance and Health-LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, BrazilPost Graduate Program in Nutrition Sciences, Federal University of Paraíba (PPGCN/UFPB), João Pessoa, BrazilDe Leve Clinic, João Pessoa, BrazilPost Graduate Program in Nutrition Sciences, Federal University of Paraíba (PPGCN/UFPB), João Pessoa, BrazilLaboratory of Applied Studies in Physical Training to Performance and Health-LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, BrazilAssociate Postgraduate Program in Physical Education – UPE/UFPB, Department of Physical Education, Federal University of Paraíba, João Pessoa, BrazilLaboratory of Applied Studies in Physical Training to Performance and Health-LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, BrazilAssociate Postgraduate Program in Physical Education – UPE/UFPB, Department of Physical Education, Federal University of Paraíba, João Pessoa, BrazilThis study aimed to verify the association between the genotypic of the receptor gene activated by peroxisome proliferators gamma 2 (PPARy2) and the body composition and the specific indicators of adiposity in practitioners physical exercises, considering nutritional intake, age, and training load as influencing factors. It was conducted a cross-sectional study with 335 adults (47.9 ± 12.7 years, 138 men, body mass index/BMI = 27.0 ± 4.9 kg/m2), practitioners of aerobic exercises in cyclical modalities (running, walking and/or cycling, who spent 328.3 ± 193.6 kcal/day on physical training). The genotyping of the Pro12Ala polymorphism was performed using the PCR-RFLP technique and the body composition measured by bioimpedance (InBody 720). Energy expenditure was based on the compendium of physical activities and caloric intake was measured by 24 h recall questionnaire. The higher prevalence was for the Pro/Pro genotype (76.1% vs. 23.9% of Pro/Ala). Pro/Pro genotypic group showed significant higher mean values for body mass (BM) (p < 0.03 for men and p < 0.02 for women) and BMI (p < 0.00 for men and p < 0.02 for women) and %FAT (p < 0.00), waist-hip ratio (WHR) (p < 0.04), and visceral fat (VF) (p < 0.00) only in men compared to Pro/Ala. Higher frequency of Pro/Pro was observed in the category indicating BMI (p < 0.00 for men and p < 0.03 for women), WRH (p < 0.03 for men and p < 0.00 for women), and %FAT (p < 0.03) (in the latter case, only among men. It was also observed that the frequency of distribution of Pro/Ala in the eutrophic category of the BMI remained independent of all influencers, while WHR and %FAT were independent of the training load, but influenced by nutritional intake and age. In women, the frequency of Pro/Ala distribution at the lowest BMI and WHR values remained independent of all confounding variables. It is concluded that the Pro12Ala polymorphism in the PPARy2 gene consistently influences indicators of body composition and adiposity, regardless of the practitioners of physical training, but the relationship needs to be considered according to age and nutritional intake.https://www.frontiersin.org/articles/10.3389/fphys.2020.633721/fullbody compositiongenetic polymorphismPPARy2energy expenditureexercise