Epistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interface
Abstract Background Quantitative traits are typically considered to be under additive genetic control. Although there are indications that non-additive factors have the potential to contribute to trait variation, experimental demonstration remains scarce. Here, we investigated the genetic basis of g...
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doaj-3865bdbf60754326a534dd0a71ee73b72021-02-07T12:47:46ZengBMCBMC Genetics1471-21562020-02-0121111710.1186/s12863-020-0816-yEpistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interfaceFrancois Besnier0Monica F. Solberg1Alison C. Harvey2Gary R. Carvalho3Dorte Bekkevold4Martin I. Taylor5Simon Creer6Einar E. Nielsen7Øystein Skaala8Fernando Ayllon9Geir Dahle10Kevin A. Glover11Population Genetics Research group, Institute of Marine ResearchPopulation Genetics Research group, Institute of Marine ResearchPopulation Genetics Research group, Institute of Marine ResearchMolecular Ecology and Fisheries Genetics Laboratory, School of Biological Sciences, Bangor UniversitySection for Marine Living Resources, National Institute of Aquatic Resources, Technical University of DenmarkSchool of Biological Sciences, University of East AngliaMolecular Ecology and Fisheries Genetics Laboratory, School of Biological Sciences, Bangor UniversitySection for Marine Living Resources, National Institute of Aquatic Resources, Technical University of DenmarkPopulation Genetics Research group, Institute of Marine ResearchPopulation Genetics Research group, Institute of Marine ResearchPopulation Genetics Research group, Institute of Marine ResearchPopulation Genetics Research group, Institute of Marine ResearchAbstract Background Quantitative traits are typically considered to be under additive genetic control. Although there are indications that non-additive factors have the potential to contribute to trait variation, experimental demonstration remains scarce. Here, we investigated the genetic basis of growth in Atlantic salmon by exploiting the high level of genetic diversity and trait expression among domesticated, hybrid and wild populations. Results After rearing fish in common-garden experiments under aquaculture conditions, we performed a variance component analysis in four mapping populations totaling ~ 7000 individuals from six wild, two domesticated and three F1 wild/domesticated hybrid strains. Across the four independent datasets, genome-wide significant quantitative trait loci (QTLs) associated with weight and length were detected on a total of 18 chromosomes, reflecting the polygenic nature of growth. Significant QTLs correlated with both length and weight were detected on chromosomes 2, 6 and 9 in multiple datasets. Significantly, epistatic QTLs were detected in all datasets. Discussion The observed interactions demonstrated that the phenotypic effect of inheriting an allele deviated between half-sib families. Gene-by-gene interactions were also suggested, where the combined effect of two loci resulted in a genetic effect upon phenotypic variance, while no genetic effect was detected when the two loci were considered separately. To our knowledge, this is the first documentation of epistasis in a quantitative trait in Atlantic salmon. These novel results are of relevance for breeding programs, and for predicting the evolutionary consequences of domestication-introgression in wild populations.https://doi.org/10.1186/s12863-020-0816-yLinkage mappingGrowthHybridIntrogressionInheritanceNon-additive |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Francois Besnier Monica F. Solberg Alison C. Harvey Gary R. Carvalho Dorte Bekkevold Martin I. Taylor Simon Creer Einar E. Nielsen Øystein Skaala Fernando Ayllon Geir Dahle Kevin A. Glover |
spellingShingle |
Francois Besnier Monica F. Solberg Alison C. Harvey Gary R. Carvalho Dorte Bekkevold Martin I. Taylor Simon Creer Einar E. Nielsen Øystein Skaala Fernando Ayllon Geir Dahle Kevin A. Glover Epistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interface BMC Genetics Linkage mapping Growth Hybrid Introgression Inheritance Non-additive |
author_facet |
Francois Besnier Monica F. Solberg Alison C. Harvey Gary R. Carvalho Dorte Bekkevold Martin I. Taylor Simon Creer Einar E. Nielsen Øystein Skaala Fernando Ayllon Geir Dahle Kevin A. Glover |
author_sort |
Francois Besnier |
title |
Epistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interface |
title_short |
Epistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interface |
title_full |
Epistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interface |
title_fullStr |
Epistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interface |
title_full_unstemmed |
Epistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interface |
title_sort |
epistatic regulation of growth in atlantic salmon revealed: a qtl study performed on the domesticated-wild interface |
publisher |
BMC |
series |
BMC Genetics |
issn |
1471-2156 |
publishDate |
2020-02-01 |
description |
Abstract Background Quantitative traits are typically considered to be under additive genetic control. Although there are indications that non-additive factors have the potential to contribute to trait variation, experimental demonstration remains scarce. Here, we investigated the genetic basis of growth in Atlantic salmon by exploiting the high level of genetic diversity and trait expression among domesticated, hybrid and wild populations. Results After rearing fish in common-garden experiments under aquaculture conditions, we performed a variance component analysis in four mapping populations totaling ~ 7000 individuals from six wild, two domesticated and three F1 wild/domesticated hybrid strains. Across the four independent datasets, genome-wide significant quantitative trait loci (QTLs) associated with weight and length were detected on a total of 18 chromosomes, reflecting the polygenic nature of growth. Significant QTLs correlated with both length and weight were detected on chromosomes 2, 6 and 9 in multiple datasets. Significantly, epistatic QTLs were detected in all datasets. Discussion The observed interactions demonstrated that the phenotypic effect of inheriting an allele deviated between half-sib families. Gene-by-gene interactions were also suggested, where the combined effect of two loci resulted in a genetic effect upon phenotypic variance, while no genetic effect was detected when the two loci were considered separately. To our knowledge, this is the first documentation of epistasis in a quantitative trait in Atlantic salmon. These novel results are of relevance for breeding programs, and for predicting the evolutionary consequences of domestication-introgression in wild populations. |
topic |
Linkage mapping Growth Hybrid Introgression Inheritance Non-additive |
url |
https://doi.org/10.1186/s12863-020-0816-y |
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