Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair

Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair

The expansion of trinucleotide repeats can have detrimental effects and give rise to a range of human diseases. Here the authors report that the mismatch repair and the base excision repair machinery can operate together to promote expansion during lesion removal.

Bibliographic Details
Main Authors: Yanhao Lai, Helen Budworth, Jill M. Beaver, Nelson L. S. Chan, Zunzhen Zhang, Cynthia T. McMurray, Yuan Liu
Format: Article
Language:English
Published: Nature Publishing Group 2016-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12465
id doaj-3879ba8a8aee40aca671630c5cc0af1e
record_format Article
spelling doaj-3879ba8a8aee40aca671630c5cc0af1e2021-05-11T11:14:51ZengNature Publishing GroupNature Communications2041-17232016-08-017111510.1038/ncomms12465Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repairYanhao Lai0Helen Budworth1Jill M. Beaver2Nelson L. S. Chan3Zunzhen Zhang4Cynthia T. McMurray5Yuan Liu6Department of Chemistry and Biochemistry, Florida International UniversityLife Sciences Division, Lawrence Berkeley National LaboratoryBiochemistry Ph.D. Program, Florida International UniversityLife Sciences Division, Lawrence Berkeley National LaboratoryDepartment of Occupational and Environmental Health, Sichuan University West China School of Public HealthLife Sciences Division, Lawrence Berkeley National LaboratoryDepartment of Chemistry and Biochemistry, Florida International UniversityThe expansion of trinucleotide repeats can have detrimental effects and give rise to a range of human diseases. Here the authors report that the mismatch repair and the base excision repair machinery can operate together to promote expansion during lesion removal.https://doi.org/10.1038/ncomms12465
collection DOAJ
language English
format Article
sources DOAJ
author Yanhao Lai
Helen Budworth
Jill M. Beaver
Nelson L. S. Chan
Zunzhen Zhang
Cynthia T. McMurray
Yuan Liu
spellingShingle Yanhao Lai
Helen Budworth
Jill M. Beaver
Nelson L. S. Chan
Zunzhen Zhang
Cynthia T. McMurray
Yuan Liu
Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair
Nature Communications
author_facet Yanhao Lai
Helen Budworth
Jill M. Beaver
Nelson L. S. Chan
Zunzhen Zhang
Cynthia T. McMurray
Yuan Liu
author_sort Yanhao Lai
title Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair
title_short Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair
title_full Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair
title_fullStr Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair
title_full_unstemmed Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair
title_sort crosstalk between msh2–msh3 and polβ promotes trinucleotide repeat expansion during base excision repair
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-08-01
description The expansion of trinucleotide repeats can have detrimental effects and give rise to a range of human diseases. Here the authors report that the mismatch repair and the base excision repair machinery can operate together to promote expansion during lesion removal.
url https://doi.org/10.1038/ncomms12465
work_keys_str_mv AT yanhaolai crosstalkbetweenmsh2msh3andpolbpromotestrinucleotiderepeatexpansionduringbaseexcisionrepair
AT helenbudworth crosstalkbetweenmsh2msh3andpolbpromotestrinucleotiderepeatexpansionduringbaseexcisionrepair
AT jillmbeaver crosstalkbetweenmsh2msh3andpolbpromotestrinucleotiderepeatexpansionduringbaseexcisionrepair
AT nelsonlschan crosstalkbetweenmsh2msh3andpolbpromotestrinucleotiderepeatexpansionduringbaseexcisionrepair
AT zunzhenzhang crosstalkbetweenmsh2msh3andpolbpromotestrinucleotiderepeatexpansionduringbaseexcisionrepair
AT cynthiatmcmurray crosstalkbetweenmsh2msh3andpolbpromotestrinucleotiderepeatexpansionduringbaseexcisionrepair
AT yuanliu crosstalkbetweenmsh2msh3andpolbpromotestrinucleotiderepeatexpansionduringbaseexcisionrepair
_version_ 1721446838116024320

Similar Items