Structural mechanisms of human RecQ helicases WRN and BLM
The RecQ family DNA helicases WRN (Werner syndrome protein) and BLM (Bloom syndrome protein) play a key role in protecting the genome against deleterious changes. In humans, mutations in these proteins lead to rare genetic diseases associated with cancer predisposition and accelerated aging. WRN and...
Main Author: | Ken eKitano |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2014-10-01
|
Series: | Frontiers in Genetics |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00366/full |
Similar Items
-
Human RecQ Helicases in DNA Double-Strand Break Repair
by: Huiming Lu, et al.
Published: (2021-02-01) -
Distinct prognosis of mRNA expression of the five RecQ DNA-helicase family members – RECQL, BLM, WRN, RECQL4, and RECQL5 – in patients with breast cancer
by: Zhu X, et al.
Published: (2018-12-01) -
Interactions with topoisomerase IIa enhance the unwinding activity of the BLM helicase on recombination substrates and are necessary for preventing chromosome breakage
by: Russell, Beatriz
Published: (2009) -
The Biochemical Characterization of Drosophila melanogaster RecQ4 Helicase
by: Capp, Christopher Lee
Published: (2011) -
Functions of BLM Helicase in Cells: Is It Acting Like a Double-Edged Sword?
by: Ekjot Kaur, et al.
Published: (2021-03-01)