Accurate Epigenetic Aging in Bottlenose Dolphins (<i>Tursiops truncatus</i>), an Essential Step in the Conservation of at-Risk Dolphins

Accurate Epigenetic Aging in Bottlenose Dolphins (<i>Tursiops truncatus</i>), an Essential Step in the Conservation of at-Risk Dolphins

Epigenetics, specifically DNA methylation, allows for the estimation of animal age from blood or remotely sampled skin. This multi-tissue epigenetic age estimation clock uses 110 longitudinal samples from 34 Navy bottlenose dolphins (<i>Tursiops truncatus</i>), identifying 195 cytosine-p...

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Main Authors: Ashley Barratclough, Cynthia R. Smith, Forrest M. Gomez, Theoni Photopoulou, Ryan Takeshita, Enrico Pirotta, Len Thomas, Abby M. McClain, Celeste Parry, Joseph A. Zoller, Steve Horvath, Lori H. Schwacke
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Journal of Zoological and Botanical Gardens
Subjects:
DNA methylation
epigenetics
aging
bottlenose dolphin
chronological age
Online Access:https://www.mdpi.com/2673-5636/2/3/30
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spelling doaj-388911f70bd841d29072aba82d899a552021-09-26T00:33:03ZengMDPI AGJournal of Zoological and Botanical Gardens2673-56362021-08-0123041642010.3390/jzbg2030030Accurate Epigenetic Aging in Bottlenose Dolphins (<i>Tursiops truncatus</i>), an Essential Step in the Conservation of at-Risk DolphinsAshley Barratclough0Cynthia R. Smith1Forrest M. Gomez2Theoni Photopoulou3Ryan Takeshita4Enrico Pirotta5Len Thomas6Abby M. McClain7Celeste Parry8Joseph A. Zoller9Steve Horvath10Lori H. Schwacke11Conservation Medicine Division, National Marine Mammal Foundation, San Diego, CA 92106, USAConservation Medicine Division, National Marine Mammal Foundation, San Diego, CA 92106, USAConservation Medicine Division, National Marine Mammal Foundation, San Diego, CA 92106, USACentre for Research into Ecological and Environmental Modelling, University of St Andrews, St Andrews KY16 9LZ2, UKConservation Medicine Division, National Marine Mammal Foundation, San Diego, CA 92106, USADepartment of Mathematics and Statistics, Washington State University, Vancouver, WA 98686, USACentre for Research into Ecological and Environmental Modelling, University of St Andrews, St Andrews KY16 9LZ2, UKConservation Medicine Division, National Marine Mammal Foundation, San Diego, CA 92106, USAConservation Medicine Division, National Marine Mammal Foundation, San Diego, CA 92106, USADepartment of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USADepartment of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USAConservation Medicine Division, National Marine Mammal Foundation, San Diego, CA 92106, USAEpigenetics, specifically DNA methylation, allows for the estimation of animal age from blood or remotely sampled skin. This multi-tissue epigenetic age estimation clock uses 110 longitudinal samples from 34 Navy bottlenose dolphins (<i>Tursiops truncatus</i>), identifying 195 cytosine-phosphate-guanine sites associated with chronological aging via cross-validation with one individual left out in each fold (R<sup>2</sup> = 0.95). With a median absolute error of 2.5 years, this clock improves age estimation capacity in wild dolphins, helping conservation efforts and enabling a better understanding of population demographics.https://www.mdpi.com/2673-5636/2/3/30DNA methylationepigeneticsagingbottlenose dolphinchronological age
collection DOAJ
language English
format Article
sources DOAJ
author Ashley Barratclough
Cynthia R. Smith
Forrest M. Gomez
Theoni Photopoulou
Ryan Takeshita
Enrico Pirotta
Len Thomas
Abby M. McClain
Celeste Parry
Joseph A. Zoller
Steve Horvath
Lori H. Schwacke
spellingShingle Ashley Barratclough
Cynthia R. Smith
Forrest M. Gomez
Theoni Photopoulou
Ryan Takeshita
Enrico Pirotta
Len Thomas
Abby M. McClain
Celeste Parry
Joseph A. Zoller
Steve Horvath
Lori H. Schwacke
Accurate Epigenetic Aging in Bottlenose Dolphins (<i>Tursiops truncatus</i>), an Essential Step in the Conservation of at-Risk Dolphins
Journal of Zoological and Botanical Gardens
DNA methylation
epigenetics
aging
bottlenose dolphin
chronological age
author_facet Ashley Barratclough
Cynthia R. Smith
Forrest M. Gomez
Theoni Photopoulou
Ryan Takeshita
Enrico Pirotta
Len Thomas
Abby M. McClain
Celeste Parry
Joseph A. Zoller
Steve Horvath
Lori H. Schwacke
author_sort Ashley Barratclough
title Accurate Epigenetic Aging in Bottlenose Dolphins (<i>Tursiops truncatus</i>), an Essential Step in the Conservation of at-Risk Dolphins
title_short Accurate Epigenetic Aging in Bottlenose Dolphins (<i>Tursiops truncatus</i>), an Essential Step in the Conservation of at-Risk Dolphins
title_full Accurate Epigenetic Aging in Bottlenose Dolphins (<i>Tursiops truncatus</i>), an Essential Step in the Conservation of at-Risk Dolphins
title_fullStr Accurate Epigenetic Aging in Bottlenose Dolphins (<i>Tursiops truncatus</i>), an Essential Step in the Conservation of at-Risk Dolphins
title_full_unstemmed Accurate Epigenetic Aging in Bottlenose Dolphins (<i>Tursiops truncatus</i>), an Essential Step in the Conservation of at-Risk Dolphins
title_sort accurate epigenetic aging in bottlenose dolphins (<i>tursiops truncatus</i>), an essential step in the conservation of at-risk dolphins
publisher MDPI AG
series Journal of Zoological and Botanical Gardens
issn 2673-5636
publishDate 2021-08-01
description Epigenetics, specifically DNA methylation, allows for the estimation of animal age from blood or remotely sampled skin. This multi-tissue epigenetic age estimation clock uses 110 longitudinal samples from 34 Navy bottlenose dolphins (<i>Tursiops truncatus</i>), identifying 195 cytosine-phosphate-guanine sites associated with chronological aging via cross-validation with one individual left out in each fold (R<sup>2</sup> = 0.95). With a median absolute error of 2.5 years, this clock improves age estimation capacity in wild dolphins, helping conservation efforts and enabling a better understanding of population demographics.
topic DNA methylation
epigenetics
aging
bottlenose dolphin
chronological age
url https://www.mdpi.com/2673-5636/2/3/30
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