Exo-circRNAs: a new paradigm for anticancer therapy
Abstract CircRNAs, as new members of long noncoding RNAs, have been the focus of recent investigation. CircRNAs feature a closed continuous loop structure without 5′-3′ polarity or a poly A tail. Many studies have reported the potential application of circRNAs in the clinic as new biomarkers and the...
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doaj-388a8e1630d54c20b830d7aebf92ef882020-11-25T02:24:20ZengBMCMolecular Cancer1476-45982019-03-0118111010.1186/s12943-019-0986-2Exo-circRNAs: a new paradigm for anticancer therapyHetian Bai0Kexin Lei1Fei Huang2Zhou Jiang3Xikun Zhou4National Clinical Research Center for Geriatrics and State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for BiotherapyNational Clinical Research Center for Geriatrics and State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for BiotherapyState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan UniversityNational Clinical Research Center for Geriatrics and State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for BiotherapyAbstract CircRNAs, as new members of long noncoding RNAs, have been the focus of recent investigation. CircRNAs feature a closed continuous loop structure without 5′-3′ polarity or a poly A tail. Many studies have reported the potential application of circRNAs in the clinic as new biomarkers and therapeutic targets in different diseases, especially for cancer. Additionally, the exosomes are important vehicles in cell-to-cell communication. And exo-circRNAs are circRNAs in exosomes which can be detected to provide additional evidence for conventional diagnostic methods and can be applied to suppress the malignant progress in cancer. In this review, we describe the biogenesis, characteristics, and functions of circRNAs and exosomes. Specifically, we present a comprehensive update of the promising role of exo-circRNAs in anticancer therapy.http://link.springer.com/article/10.1186/s12943-019-0986-2CircRNAsExosomesExo-circRNAsCancer therapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hetian Bai Kexin Lei Fei Huang Zhou Jiang Xikun Zhou |
spellingShingle |
Hetian Bai Kexin Lei Fei Huang Zhou Jiang Xikun Zhou Exo-circRNAs: a new paradigm for anticancer therapy Molecular Cancer CircRNAs Exosomes Exo-circRNAs Cancer therapy |
author_facet |
Hetian Bai Kexin Lei Fei Huang Zhou Jiang Xikun Zhou |
author_sort |
Hetian Bai |
title |
Exo-circRNAs: a new paradigm for anticancer therapy |
title_short |
Exo-circRNAs: a new paradigm for anticancer therapy |
title_full |
Exo-circRNAs: a new paradigm for anticancer therapy |
title_fullStr |
Exo-circRNAs: a new paradigm for anticancer therapy |
title_full_unstemmed |
Exo-circRNAs: a new paradigm for anticancer therapy |
title_sort |
exo-circrnas: a new paradigm for anticancer therapy |
publisher |
BMC |
series |
Molecular Cancer |
issn |
1476-4598 |
publishDate |
2019-03-01 |
description |
Abstract CircRNAs, as new members of long noncoding RNAs, have been the focus of recent investigation. CircRNAs feature a closed continuous loop structure without 5′-3′ polarity or a poly A tail. Many studies have reported the potential application of circRNAs in the clinic as new biomarkers and therapeutic targets in different diseases, especially for cancer. Additionally, the exosomes are important vehicles in cell-to-cell communication. And exo-circRNAs are circRNAs in exosomes which can be detected to provide additional evidence for conventional diagnostic methods and can be applied to suppress the malignant progress in cancer. In this review, we describe the biogenesis, characteristics, and functions of circRNAs and exosomes. Specifically, we present a comprehensive update of the promising role of exo-circRNAs in anticancer therapy. |
topic |
CircRNAs Exosomes Exo-circRNAs Cancer therapy |
url |
http://link.springer.com/article/10.1186/s12943-019-0986-2 |
work_keys_str_mv |
AT hetianbai exocircrnasanewparadigmforanticancertherapy AT kexinlei exocircrnasanewparadigmforanticancertherapy AT feihuang exocircrnasanewparadigmforanticancertherapy AT zhoujiang exocircrnasanewparadigmforanticancertherapy AT xikunzhou exocircrnasanewparadigmforanticancertherapy |
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1724856198845431808 |