CLINICAL CASES OF FOCAL PULMONARY TUBERCULOSIS IN CHILDREN WITH MINIMUM INVOLVEMENT IN MULTIDRUG RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS

• Main Authors: M. F. Gubkina, N. V. Yukhimenko, Yu. Yu. Khokhlova, I. Yu. Petrakova, S. G. Mikhailov
• Format: Article
• Language: Russian
• Published: NEW TERRA Publishing House 2015-03-01
• Series: Tuberkulez i Bolezni Lëgkih
• Subjects: focal pulmonary tuberculosis; multidrug resistance in mycobacterium tuberculosis
• Online Access: https://www.tibl-journal.com/jour/article/view/353

The paper describes two clinical cases of progressive focal pulmonary tuberculosis in 11- and 12-year-old children. Chemotherapy regimen III was used because of the absence of bacterial excretion and the mild involvement of lung tissue. Following 4-month therapy, a focal decay appeared in the left lung (C1-2) of the former patient. The female patient was operated on. M. tuberculosis DNA was identified by PCR in her intraoperative specimen; isoniazid and rifampicin resistance was determined. Occult multidrug resistance was a reason for ineffective treatment with first-line drugs. After 6-month chemotherapy, the size of a focus in the right left (C1-2) doubled and a new focal shadow emerged in the lung of the latter patient. The progression was related to the untimely obtained information on a broad drug resistance in the infection pathogen and to the chemotherapy performed by ignoring these data. Chemotherapy correction in view of the data of a drug susceptibility test could provide a positive result in both cases.